Abstract:Objective To study the changes of liver function indexes and their relationship with IIEF-5, MSF-4 scores in erectile dysfunction (ED) patients. Methods We collected 100 cases of ED patients (ED group) and 48 cases normal healthy control (N group) from May 2015 to December 2017 in andrology department in the first and fouth affiliated hospital affiliated to Xinjiang medical university, obtained the related data such as international index of erectile function 5 items (IIEF-5) and male sexual function 4 items (MSF-4) scores and blood, then detected the changes of liver function using automatic blood analyzer, and analyze their relationship with IIEF-5, MSF-4 scores in ED patients. Results Compared with N group, ED group showed lower IIEF-5 and MSF-4 scores; higher ALP, ChE level; lower TP, TBILI, TBA (P?0.05). Increased ALP, ChE and decreased TP, TBILI, TBA were showed in IIEF-5 < 12, MSF-4 < 9 groups compared with IIEF-5 ≥ 12, MSF-4≥ 9 groups (P?0.05). Conclusion Changes of liver function may result in significant reductions in erectile function and libido in ED patients. Test of liver function combined with IIEF-5 and MSF-4 scores can provide reference data for clinical diagnosis and treatment of ED.