Abstract:Objective To investigate the effect of intercostal nerve block and serratus plane block on analgesia after single-hole thoracoscopic wedge resection of lung. Methods A retrospective analysis was made on 60 patients who underwent single-hole thoracoscopic wedge resection from March 2018 to March 2019 in our hospital. According to the regional block method, the patients were divided into the observation group (33 cases of intercostal nerve block + serratus plane block) and the control group (27 cases of serratus plane block). The gender, age, BMI, ASA grade, bleeding volume, operation time, pain VAS score at 4, 12, 24 and 48 hours after operation, PCIA pressing times after operation, additional medication times after operation, PCIA-related side effects after operation, pulmonary complications after operation, chest tube removal time after operation, SpO2 activity time after operation, hospital stay were compared between the two groups. Results There was no significant difference in general data, bleeding volume and operation time between the two groups (P?>?0.05). The VAS scores at different time points after operation and VAS scores after operation in the two groups had statistical significance (P?0.05), and there was interaction between groups and processing times (P?0.05). The incidence of PCIA-related side effects after operation in the observation group was lower than that in the control group, but there was no significant difference between the two groups (P?>?0.05). Compared with the control group, the observation group reduced the times of PCIA pressing and additional medication after operation, reduced the incidence of pulmonary complications (P?0.05), increased arterial oxygen concentration (P?0.05), shortened the time of thoracic tube extraction, hospitalization and the first time out of bed activity time in advance (P?0.05). Conclusion Compared with the simple anterior serratus block, the combined regional nerve block with direct vision non-intracostal nerve block and anterior serratus block can relieve the pain of patients after single-hole thoracoscopic pulmonary wedge resection of lung, reduce the pulmonary complications and facilitate the rapid recovery of patients.