慢性阻塞性肺疾病患者IL-8、LTB4、PGE2 水平 及与肺功能受损严重程度的相关性

Correlation between IL-8, LTB4 and PGE2 expression and severity of pulmonary function impairment in patients with chronic obstructive pulmonary disease

摘要:

目的 探究白细胞介素-8（IL-8）、白三烯B4（LTB4）、前列腺素E2（PGE2） 在慢性阻 塞性肺疾病（COPD）患者中的表达水平及与肺功能受损严重程度的相关性。方法 前瞻性选择2018 年 5 月—2019 年5 月廊坊市人民医院收治的98 例急性期COPD 患者作为病例组，另取同期该院健康体检者 50 例作为对照组。比较两组血清IL-8、LTB4、PGE2 水平，比较不同肺功能受损严重程度患者血清IL-8、 LTB4、PGE2 水平，分析其与肺功能受损严重程度的相关性，采用多因素Logistic 回归分析COPD 的影响因素。 结果 病例组血清IL-8、LTB4、PGE2 水平高于对照组（P <0.05）。不同肺功能受损严重程度患者血清 IL-8、LTB4、PGE2 水平比较，差异有统计学意义（P <0.05），Ⅳ级> Ⅲ级> Ⅱ级> Ⅰ级。COPD 患者血清 IL-8、LTB4、PGE2 水平与肺功能受损严重程度均呈正相关（r s=0.712、0.561、和0.476，P <0.05）。血清IL- 8[Ol ^ R=2.268（95% CI ：1.272，3.948）]、LTB4[Ol ^ R=1.847（95% CI ：1.161，2.746）]、PGE2[Ol ^ R=2.108（95% CI ：1.202，3.326）] 是COPD 的危险因素（P <0.05）。结论 IL-8、LTB4、PGE2 在COPD 患者血清中高表 达，与COPD 发生及肺功能受损严重程度相关，有望成为预测COPD 发生、发展的指标之一。

Abstract:

Objective To investigate the correlation between interleukin-8 (IL-8), leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) expression and severity of pulmonary function impairment in patients with chronic obstructive pulmonary disease (COPD). Methods Ninety-eight acute COPD patients (case group) and 50 physical examinees (control group) in our hospital from May 2018 to May 2019 were selected. Serum IL-8, LTB4, and PGE2 levels were detected, and then the comparison was made between groups and among COPD patients with different severity of pulmonary function impairment. Spearman correlation analysis was used to analyze the correlation between IL-8, LTB4 and PGE2 expression and severity of pulmonary function impairment. Multivariate logistic regression was used to analyze the influencing factors of COPD. Results The levels of serum IL-8, LTB4 and PGE2 in the case group were significantly higher than those in the control group (P < 0.05). Among all patients, serum IL- 8, LTB4, and PGE2 levels were highest in patients with grade Ⅳ pulmonary function impairment, followed by the grade Ⅲ, grade II and grade I, and paired comparison showed statistic differences (P < 0.05). Serum IL-8, LTB4, and PGE2 levels were positively correlated with the severity of pulmonary function impairment (rs =0.712, 0.561, 0.476, P < 0.05) and were independent risk factors for COPD [Ol^RIL-8=2.268 (95% CI: 1.272, 3.948); Ol^RLTB4=1.847 (95% CI: 1.616, 2.746); Ol^RPGE2=2.108 (95% CI: 1.202, 3.326)] (P < 0.05). Conclusions IL-8, LTB4 and PGE2 are highly expressed in serum of COPD patients and significantly correlated with the severity of pulmonary function impairment in COPD, and potentially can be established as reliable predictors of the occurrence and development of COPD.