血清uMtCK、PG、G-17 及CA72-4 联合检测 在胃癌辅助诊断中的价值

The value of serum uMtCK, PG, G-17 and CA72-4 in the auxiliary diagnosis of gastric cancer

摘要:

目的 探讨血清广泛型线粒体肌酸激酶（uMtCK）、胃蛋白酶原（PG）、胃泌素-17（G-17）、糖 类抗原72-4（CA72-4）联合检测在胃癌辅助诊断中的应用价值。方法 选取2018 年3 月—2019 年10 月在 青岛市中心医院住院治疗的90 例胃癌患者作为研究组，另选该院同期90 例胃部良性病变患者作为对照组。采 用酶联免疫吸附试验检测血清uMtCK 水平；采用化学发光法检测PG Ⅰ、PG Ⅱ及G-17 水平；采用电化学发 光法检测CA72-4 水平，探讨单独检测和联合检测的诊断价值。结果 研究组血清uMtCK、PG Ⅱ、G-17 及 CA72-4 水平高于对照组（P <0.05），而PG Ⅰ、PG Ⅰ /PG Ⅱ（PGR）水平低于对照组（P <0.05）。研究组血 清uMtCK、PG Ⅰ、PG Ⅱ、PGR、G-17 及CA72-4 的阳性率高于对照组（P <0.05），其联合检测的阳性率也 高于对照组（P <0.05）。研究组血清uMtCK、PG Ⅱ、G-17 及CA72-4 联合检测的敏感性为88.89%（95% CI ： 0.801，0.942），准确性为86.11%（95% CI ：0.802，0.905），均高于各单项指标检测（P <0.05）。AUC 结果显示 uMtCK、PG Ⅱ、G-17 和CA72-4 联合检测诊断价值最大（AUC=0.976），PG Ⅰ诊断价值最小（AUC=0.810） （P <0.05）。结论 血清uMtCK、PG Ⅰ、PG Ⅱ、PGR、G-17 及CA72-4 联合检测对胃癌具有较好的诊断价值。

Abstract:

Objective To investigate the value of serum uMtCK (ubiquitous mitochondrial creatine kinase), PG I (pepsinogen I), PG II (pepsinogen II), G-17 (gastrin-17) and CA72-4 (carbohydrate antigen 72-4) in the auxiliary diagnosis of gastric cancer. Methods A total of 90 patients with gastric cancer from March 2018 to October 2019 were selected as the study group, with 90 cases of benign gastric lesions as the control group during the same period. The levels of serum uMtCK were detected by ELISA, the levels of serum PG I, PG II and G-17 were determined by chemiluminescence method, and the levels of CA72-4 were measured by electrochemiluminescence method. Results The levels of uMtCK, PG II, PGR, G-17 and CA72-4 in the study group were higher than those of the control group (P < 0.05), whereas the levels of PG I were lower than those of the control group (P < 0.05). The positive detection rates of uMtCK, PG II, G-17 and CA72-4, as well as the combined detection in the study group were all higher than those of the control group (P < 0.05). The sensitivity of combined detection was 88.89% (95% CI: 0.801, 0.942), while the accuracy thereof was 86.11% (95% CI: 0.802, 0.905), both of which were significantly higher than those of the single test of each indicator (P < 0.05). According to the ROC results, the diagnostic value of combined detection was the highest (AUC=0.976), and that of PG I was the lowest (AUC=0.810). Conclusions The combined detection of uMtCK, PG I, PG II, PGR, G-17 and CA72-4 is of great value in the diagnosis of gastric cancer.