细胞自噬与免疫系统的关系及其在乳腺癌免疫治疗中的应用

Relationship between autophagy and immune system and its application in breast cancer immunotherapy

摘要:

自噬是通过在溶酶体或液泡中降解破坏的蛋白或细胞器并再利用，实现真核细胞稳态、持续更新的保守进化过程。近年研究发现，自噬与免疫应答密切相关，且在乳腺肿瘤进展中发挥重要作用。文章综述了参与细胞自噬调控的复合物、细胞自噬与免疫系统关系、自噬在肿瘤中的作用、细胞自噬在乳腺癌免疫治疗中的应用，旨在为自噬与乳腺癌免疫治疗及临床疗效的相关研究及改善患者预后提供参考。

Abstract:

Autophagy achieves a steady evolutionary process of eukaryotic cell homeostasis and continuous renewal by degrading damaged proteins or organelles in lysosomes or vacuoles. In recent years, studies have found that autophagy is closely related to immune response and plays an important role in the development of breast cancer cells. This article reviews the complexes involved in the regulation of autophagy, the relationship between autophagy and immune system, the role of autophagy in tumors, and the application of autophagy in breast cancer immunotherapy, aimed to improve the prognosis of patients and provide reference for autophagy, immunotherapy of breast cancer and the correlation between clinical benefits and research