益赛普对寻常型银屑病血小板活性的影响

Clinical analysis of etanercept improves platelet activity in patients with psoriasis vulgaris

摘要:

目的 评价益赛普治疗寻常型斑块状银屑病的疗效，分析益赛普治疗前后患者血小板计数（PLT）、平均血小板体积（MPV）、血小板分布宽度（PDW）的变化，探讨MPV和银屑病面积与严重性指数（PASI）评分的相关性。方法 寻常性银屑病患者采用益赛普治疗24周，治疗前、中、后均予血常规检查和评估PASI，比较其变化。采用Pearson法分析MPV与PASI的相关性。结果 经益赛普治疗后，治疗前后的PLT、MPV、PDW比较，差异有统计学意义（P?<0.05）。MPV与PASI呈正相关（r?=0.147，P?=0.030）。结论 益赛普治疗寻常型银屑病有效，MPV可作为临床上评估银屑病皮损严重程度及治疗效果的参考指标。

Abstract:

Objective To evaluate the efficacy of etanercept in the treatment of psoriasis vulgaris, to analyze the changes of PLT, MPV, PDW levels before and after treatment, and to investigate the correlation between the average platelet volume (MPV) and PASI score of patients with psoriasis vulgaris. Methods The experimental group had been received treatment of etanercept for 24 weeks. Before, during and after treatment, blood tests and PASI score were carried out, and the results of the three times were compared. The correlation between MPV and PASI was analyzed by Pearson method. Results After treatment of etanercept, the levels of PLT, MPV and PDW were significantly different with those before treatment (P?