Abstract:Hydrogen is a colorless and tasteless reducing gas generally considered physiologically inert, and its function on organisms has remained largely overlooked. Nevertheless, a growing number of studies in recent years have reported therapeutic effects of hydrogen in treating the diseases of heart, brain, lung, and other organs. Some studies demonstrated that the therapeutic functions of hydrogen mainly resulted from its antioxidant, antiinflammatory, anti-apoptotic, and autophagy-regulatory effects. This article reviews the latest research progress of the biological effects of hydrogen in treating diseases.