乙酰半胱氨酸泡腾片对放射性肺炎患者体液因子表达的影响*

Effect of acetylcysteine effervescent on expression of humoral factors in patients with radiation pneumonia*

摘要:

目的 研究乙酰半胱氨酸泡腾片对肺癌患者放疗后发生放射性肺炎时体液因子表达的影响。方法 选取2016年5月—2017年7月河北北方学院附属第一医院收治的放疗后发生放射性肺炎并需继续放疗的肺癌患者80例。采用简单随机化方法分为观察组和对照组，每组40例。对照组给予单纯放射治疗，观察组在对照组基础上给予乙酰半胱氨酸泡腾片口服治疗。观察两组患者的治疗有效率，应用药物前后C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）、转化生长因子-β（TGF-β）、表面活性物质结合蛋白（SP-A、SP-D）和谷胱甘肽（GSH）的表达情况。结果 治疗后，观察组治疗有效率85.00%，高于对照组（65.00%）（P?<0.05）；观察组患者CRP、TNF-α、IL-6、IL-8和IL-10水平均低于对照组（P?<0.05）；观察组患者SP-A、SP-D和GSH水平高于对照组（P?<0.05）。结论 乙酰半胱氨酸泡腾片可提高放射性肺炎临床治疗总有效率，降低炎症因子表达，提高SP-A、SP-D及GSH水平，值得临床推广。

Abstract:

Objective To study the effect of acetylcysteine effervescent tablets on the expression of humoral factors in patients with radiation pneumonia. Methods From Mary 2016 to July 2017, 80 patients with radiation pneumonia in our hospital were selected, and divided into observation group and control group by simple randomized, 40 patients in each group. Patients in control group were treated by pure radiation therapy, and patients in observation group were treated by acetylcysteine effervescent tablets on the base of radiation therapy. The efficacy rate, application of inflammatory factors (CRP, TNF-alpha, IL-6, IL-8 and IL-10) before and after drug, TGF-beta, lung surface active substance (SP-A, SP-D) and expression of GSH were observed. Results After treatment, the effecacy rate of treatment in the observation group (85.00%) was significantly higher than that in the control group (65.00%) (P?