硫化氢在心血管疾病中的研究进展*

Recent research of H2S and autophagy in cardiovascular diseases*

摘要:

硫化氢被认为是重要的内源性气体递质，可以在哺乳动物的组织中合成并自由地穿过细胞膜，通过多种机制对心肌细胞发挥保护作用，并在心血管系统内发挥许多生物学效应。内源性硫化氢和外源性硫化氢供体，如硫氢化钠、硫化二钠、P-（4-甲氧基苯基）-p-4-吗啉代二硫代磷酸等的释放，在包括动脉粥样硬化、高血压、心肌损伤和心力衰竭等心血管疾病中发挥重要作用。然而，关于硫化氢在健康及疾病状态中的作用及机制仍待更深入地探讨。该文将对硫化氢在心血管疾病中的研究进展进行概述，并讨论其作用机制。

Abstract:

Hydrogen sulfide (H2S) is considered being an important endogenous gas transmitter that can be synthesized and freely passed through cell membranes in mammalian tissues. It protects cardiomyocytes through a variety of mechanisms and exerts many biological effects in the cardiovascular system. The release of endogenous H2S and exogenous H2S donor, such as sodium hydrogen sulfide (NaHS), disodium sulfide (Na2S), and P- (4-methoxyphenyl) -p-4-morpholino dithiophosphate (GYY4137), plays a role in many cardiovascular diseases such as atherosclerosis, hypertension, myocardial damage, and heart failure. However, the function and mechanism of H2S in health and disease states remains to be explored. This article will summarize the research progress of H2S in cardiovascular diseases, and discuss its mechanism of action in depth.