白藜芦醇作用于SIRT1影响认知功能的机制研究进展*

Advances in research on the mechanism of resveratrol improving cognitive function via action on SIRT1*

摘要:

认知功能减退是与年龄相关的疾病，目前仍无有效的治疗手段。白藜芦醇是一种多酚类化合物，可通过多种途径改善大脑的功能状态，SIRT1的激活是白藜芦醇发挥作用的关键。该文对白藜芦醇的作用机制研究进展，包括抗氧化、抗炎、抗凋亡、改善突触可塑性、增加脑血流量及自噬作用进行综述。

Abstract:

Cognitive impairment is an age-related disease, for which no effective treatment has been established yet. Resveratrol was a kind of polyphenol that could improve brain function via multiple ways. SIRT1 activation was the key to resveratrol function. This paper is an overview of advances in research on the mechanism of resveratrol, and its antioxidant, anti-inflammatory, anti-apoptotic, synaptic plasticity improving, cerebral blood flow increasing, and autophagy enhancing effects.