经颅磁刺激联合ESDM对孤独症患儿的疗效分析*

Therapeutic effect of transcranial magnetic stimulation combined with ESDM on children with autism*

摘要:

目的 探讨经颅磁刺激联合早期介入丹佛康复训练模式（ESDM）对孤独症患儿的治疗效果。方法 采用巢式病例对照研究法，以确诊孤独症为研究起点，以治疗6个月为研究终点，选取2016年1月—2018年6月徐州市儿童医院确诊并治疗的孤独症患儿患者92例作为研究对象。分为常规康复组（常规康复训练治疗）和颅磁丹佛组（经颅磁刺激联合ESDM治疗），每组46例。对比分析常规康复组和颅磁丹佛组的韦氏儿童认知功能（WISC）评分、儿童孤独症症状（CARS）评分、孤独症行为（ABC）评分及临床疗效的差异。结果 治疗后常规康复组和颅磁丹佛组的WISC和ABC评分较治疗前提高（P?<0.05），颅磁丹佛组升幅更大（P?<0.05）；治疗后常规康复组和颅磁丹佛组的CARS评分较治疗前降低（P?<0.05），颅磁丹佛组降幅更大（P?<0.05）；颅磁丹佛组治疗有效率（84.78%）优于常规康复组（65.22%）（P?<0.05）。结论 经颅磁刺激联合ESDM能更有效地改善孤独症症状，在小儿孤独症治疗中的临床价值确切。

Abstract:

Objective To observe the therapeutic effect of transcranial magnetic stimulation combined with early intervention of Early Start Denver Model (ESDM) on autistic children. Methods Autistic children ( diagnosed and treated in our hospital from January 2016 to June 2018) were divided into routine rehabilitation group (46 cases were given routine rehabilitation training) and cranial magnetic Denver group (46 cases were given transcranial magnetic stimulation combined with ESDM therapy), with nested case-control study (with diagnosis as the starting point and treatment for 6 months as the end point). The differences of WAIS score, CARS score, ABC score, and clinical efficacy between routine rehabilitation group and cranial magnetic Denver group were compared and analyzed. Result After treatment, WAIS score and ABC score showed that the routine rehabilitation group and cranial magnetic Denver group increased significantly (P?