早产儿支气管肺发育不良的危险因素分析

Clinical features analysis of bronchopulmonary dysplasia for premature infants

摘要:

目的 分析早产儿支气管肺发育不良（BPD）的危险因素。方法 回顾性分析胎龄<34周的早产儿225例，分为BPD组23例（包括轻度组18例和中重度组5例）和非BPD组202例，采用多因素Logistic回归分析患儿发生BPD的危险因素。结果 Logistic回归分析结果显示，胎龄[OlR=2.02（95% CI：1.13，4.25）]、脓毒血症[OlR=1.79（95% CI：1.54，2.41）]、机械通气时间[OlR=1.83（95% CI：1.27，3.62）]为<34周早产儿发生BPD的危险因素。结论 胎龄、脓毒血症、机械通气时间是早产儿发生BPD的危险因素。减少有创通气可以防治BPD。

Abstract:

Objectives To investigate risk factors associated with bronchopulmonary dysplasia (BPD) by our analyzing clinical data in neonatal intensive care unit (NICU). Methods A retrospective study was performed on the hospitalization data of infants with gestational age < 34 weeks. Totally 225 infants were divided into BPD group (23cases, including mild BPD group and moderate-severe BPD group) and non-BPD group (202 cases) according to the diagnostic criteria. We compared antenatal period data and treatment data of premature infants between BPD group and non-BPD groups to find out significant indexes analyzed by multifactors Logistic regression analysis. Results Multivariable logistic regression analysis indicated that gestational age [OlR??=?2.02, (95% CI: 1.13, 4.25)], sepsis [OlR?=?1.79, (95% CI: 1.54, 2.41], mechanical ventilation time [OlR?=?1.83, (95% CI: 1.27, 3.62)] were significant risk factors for BPD in premature infants. Conclusion Gestational ages, Sepsis and mechanical ventilation time are the risk factors of BPD among premature infants, as well as related to the severity of BPD. BPD can be prevented by reducing time of invasive ventilation.