轻度子痫前期孕妇维生素A水平与不良妊娠结局的关系*

Relationship between vitamin A and adverse pregnancy outcomes in pregnant women with mild preeclampsia*

摘要:

目的 分析轻度子痫前期孕妇维生素A水平与不良妊娠结局的关系。方法 选取2017年1月—2018年9月于大连市妇幼保健院产科产检并分娩的孕妇797例。其中，轻度子痫前期组597例，正常对照组200例，回顾性分析比较两组妊娠期维生素A水平，并进一步比较轻度子痫前期组维生素A充足者与不足者妊娠期并发症、妊娠结局及新生儿情况。结果 轻度子痫前期组妊娠期维生素A水平低于对照组（P?<0.05）；轻度子痫前期组孕妇中，维生素A不足组发生妊娠期并发症（包括胎膜早破、胎儿生长受限、胎盘早剥、先兆早产、产后出血）和新生儿围生期情况（包括出生低体重儿、胎儿窘迫、新生儿窒息）的概率均高于维生素A充足组（P?<0.05）。结论 轻度子痫前期孕妇维生素A水平低于正常孕妇，妊娠期维生素A水平是影响轻度子痫前期孕妇妊娠结局的一个因素。

Abstract:

Objective To analyze the relationship between vitamin A and adverse pregnancy outcomes in pregnant women with mild preeclampsia. Methods A total of 797 cases of pregnant women delivered in Dalian maternal and child health care hospital from January 2017 to September 2018 were selected, in which 597 cases were preeclampsia pregnancies (preeclampsia group) and 200 cases were normal pregnancies (healthy control group). The levels of vitamin A during pregnancy in the two groups were retrospectively analyzed and compared, and the pregnancy complications, pregnancy outcomes, and neonatal status in the preeclampsia group with adequate and inadequate vitamin A were furtherly compared. Results The levels of vitamin A during pregnancy in the preeclampsia group were lower than those in the healthy control group (P?