类风湿关节炎合并骨质疏松的发病机制和治疗进展*

Pathogenesis and treatment progress of rheumatoid arthritis with osteoporosis*

摘要:

随着我国人口老龄化日益加重，骨质疏松的患者也愈来愈多，并且呈逐渐年轻化的趋势。性激素、钙吸收下降、炎症因子等多种因素均可能引起骨质疏松。继发性原因导致的骨质疏松占绝大多数，在风湿免疫疾病中，部分疾病如类风湿关节炎、强直性脊柱炎、骨关节炎等均可导致骨质疏松，其原因可能与肿瘤坏死因子、白细胞介素等炎症因子相关。该文对类风湿关节炎合并骨质疏松的发病机制和治疗进展进行综述。

Abstract:

With the increasing aging population in China, the number of patients with osteoporosis is as well on the rise, and the onset age gradually tends to be younger. Various factors such as sex hormones, decreased calcium absorption, and the effects of certain inflammatory factors may contribute to osteoporosis. Generally, osteoporosis secondary to other disorders accounts for the vast majority. Some rheumatic diseases including rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis can cause osteoporosis, which may be related to certain inflammatory factors such as tumor necrosis factor and interleukin. This article will provide a detailed review of the pathogenesis and treatment of osteoporosis secondary to rheumatoid arthritis.