宫颈环扎术联合阿托西班治疗宫颈机能不全的临床效果

Analysis on clinical efficacy of cervical cerclage combined with atosiban in the treatment of cervical incompetence

摘要:

目的?评价宫颈环扎术联合阿托西班治疗宫颈机能不全的临床价值。方法?选取2015年6月—2019年8月于西南医科大学附属医院行宫颈环扎术治疗宫颈机能不全的患者70例，32例患者宫颈环扎术后使用阿托西班抑制宫缩作为阿托西班组，38例术后未使用阿托西班抑制宫缩作为常规组。分析两组的宫缩抑制、不良反应、并发症、延长孕周时间及妊娠结局。结果?阿托西班组宫缩抑制27例，抑制宫缩有效率为84.4%，仅2例出现轻微不良反应，未出现因严重不良反应。阿托西班组不良反应发生率较常规组高（P?<0.05），常规组早产率较阿托西班组高（P?<0.05），新生儿Apgar评分较阿托西班组低（P?<0.05）。结论?阿托西班能有效抑制宫缩，阿托西班联合宫颈环扎能明显延长孕周，降低早产率，无明显不良反应，妊娠结局良好。

Abstract:

Objective To evaluate the clinical value of atosiban combined with cervical cerclage in the treatment of cervical insufficiency.?Methods?Clinical data of 70 patients with cervical insufficiency treated by cervical cerclage in the Affiliated Hospital of Southwest Medical University from June 2015 to August 2019 were collected for retrospective analysis, among which 32 patients who were administered atosiban for the suppression of uterine contraction were set as atosiban group, and 38 cases without the use of atosiban after surgery were included into the routine group. The uterine contraction inhibition, adverse reactions, complications, prolonged duration of pregnancy and pregnancy outcomes were analyzed.?Results?There were 27 cases occurring uterine contraction inhibition in the atosiban group with an effective rate of 84.4% in inhibiting uterine contraction, and only 2 cases occurred slight adverse reactions but no case withdrew atosiban treatment due to severe adverse reactions. Compared with the routine group, the incidences of adverse reactions and premature delivery rate in atosiban group were lower (P < 0.05). Besides, the Apgar score of the newborn of the atosiban group was higher than that of the routine group (P?