中国中老年人群症状性膝骨关节炎与髋部骨折的关系*

Association between symptomatic knee osteoarthritis and hip fracture in Chinese middle-aged and elderly population*

摘要:

目的??研究中国中老年人群症状性膝骨关节炎与髋部骨折的关系。方法?基于2015年中国健康与养老追踪调查数据，采用多因素Logistic回归模型分析症状性膝骨关节炎与髋部骨折的关系，并依据性别、年龄和体重指数（BMI）进行亚组分析。结果?本研究共纳入研究对象17?830例，其中，男性8?405例，女性9?425例；年龄≥70岁占比20.5%。症状性膝骨关节炎患者BMI（23.9±3.9）kg/m2，非症状性膝骨关节炎研究对象BMI（23.8±3.7）kg/m2。症状性膝骨关节炎与非症状性膝骨关节炎研究对象在性别、年龄、BMI、文化程度、饮酒、吸烟、摔倒和疾病方面比较，差异均有统计学意义（P?

Abstract:

Objective??To analyze the relationship between symptomatic knee osteoarthritis and hip fracture in Chinese middle-aged and elderly population.?Methods?Based on China Health and Retirement Longitudinal Study in 2015, Logistic regression analysis was conducted to examine the relationship between symptomatic knee osteoarthritis and hip fracture, and the results were further analyzed according to gender, age and body mass index (BMI) subgroups.?Results?A total of 17830 subjects (8405 males and 9425 females) were included in the analysis, with 20.52% of the participants aged ≥?70. Average BMI of symptomatic knee osteoarthritis participants and non-symptomatic knee osteoarthritis participants were (23.9?±?3.9) kg/m2 and (23.8?±?3.7) kg/m2, respectively. There were significant differences in gender, age, BMI, education level, history of drinking, smoking, fall and underlying diseases between symptomatic knee osteoarthritis participants and non-symptomatic knee osteoarthritis participants. The odds ratio (OR) (95% confidence interval [CI]) of hip fracture in symptomatic knee osteoarthritis patients to that in non-symptomatic knee osteoarthritis individuals was 2.56 (2.01, 3.26). Adjusted for age, gender and BMI, symptomatic knee osteoarthritis [OR?=?2.81, (95% CI: 2.14, 3.69)] was a risk factor of hip fracture. Adjusted for multiple factors (age, gender, BMI, education level, history of smoking, drinking, fall, high blood pressure, diabetes, heart disease, chronic lung disease, stroke and malignant tumors), symptomatic knee osteoarthritis [OR?=?2.20, (95% CI: 1.64, 2.96)] was still a risk factor of hip fracture. Besides, the results of subgroup analyses of gender, age and BMI as well indicated that symptomatic knee osteoarthritis was a risk factor for hip fracture.?Conclusions?The prevalence of symptomatic knee osteoarthritis is positively correlated with that of hip fracture among Chinese middle-aged and elderly population, which indicates that these two diseases often coexist in the Chinese population. This finding provides a theoretical basis for further elucidating on the potential causal relationship between the two diseases and exploring their potential prevention and treatment targets.