细胞周期蛋白E1基因在卵巢癌诊治中的作用*

Application of CCNE1 in diagnosis and treatment of ovarian tumor*

摘要:

肿瘤细胞中基因拷贝数变异可影响细胞稳态，导致细胞恶变。细胞周期蛋白E1 基因（CCNE1） 编码细胞周期蛋白E1 （Cyclin E1），CCNE1 扩增或过表达改变Cyclin E1 的表达，并影响其他基因的表达， 参与多种恶性肿瘤的发生、发展。CCNE1 扩增或过表达与卵巢癌的发生、耐药、靶向治疗及预后密切相关。 该文综述CCNE1 表达在卵巢癌诊治中的作用，以期有助于探寻新的卵巢癌治疗方法。

Abstract:

Genomic instability with copy number alterations in tumor cells can affect cell homeostasis, which can lead to malignant changes in cells. CCNE1 encodes Cyclin E1 protein. CCNE1 amplification or overexpression changes the expression of Cyclin E1 and affects a large fraction of genome. It is involved in the development of various malignant tumors. CCNE1 amplification or overexpression is closely related to the occurrence, drug resistance, targeted therapy and prognosis of ovarian cancer. Therefore, this paper reviews the role of CCNE1 in the diagnosis and treatment of ovarian cancer on the purpose of exploring new therapy for ovarian cancer.