复发性卵巢癌的药物治疗及进展

Drug treatment and research progress of recurrent ovarian cancer

摘要:

卵巢癌在女性妇科肿瘤中死亡率第一，且复发率高。复发性卵巢癌无法治愈，目前复发性卵巢 癌的治疗以改善患者生活质量，延长患者无进展生存期及总生存期为目的。分子靶向治疗复发性卵巢癌是 研究热点，靶向药物包括抗血管生成药物、聚二磷酸腺苷核糖聚合酶抑制剂及免疫检查点抑制剂。该文重 点对复发性卵巢癌的药物治疗进展进行综述。

Abstract:

Ovarian cancer has the highest mortality among female gynecological tumors and has a high recurrence rate. There is no cure for recurrent ovarian cancer, and the current treatment of recurrent ovarian cancer is aimed at improving the quality of life of patients, prolonging progression-free survival and overall survival. Molecular targeted therapy for recurrent ovarian cancer is a research hot-spot. Targeted drugs include anti-angiogenesis drugs, PARP inhibitors and immune checkpoint inhibitors. This review focuses on the advances of drug therapy for recurrent ovarian cancer.