IgA 肾病与微生物免疫的研究进展*

Advances in research on IgA nephropathy and microbe-related immune mechanisms*

摘要:

IgA 肾病（IgAN） 是最常见的慢性肾小球肾炎之一，但明确的病因和发病机制仍不清楚。该疾 病与多种潜在机制有关，其中黏膜免疫反应是重要的致病因素之一。而微生物产生的IgA 蛋白酶和细胞因子 都会在免疫作用中引起相应的组织学改变。目前，微生物的多样性分析与IgAN 患者的临床疗效和预后有紧 密的联系。随着致病机制相关研究的开展，许多IgAN 的临床治疗数据也逐渐被发现。因此，探讨IgAN 与 微生物相关的免疫机制对IgAN 的有效治疗具有重要意义。

Abstract:

IgA nephropathy (IgAN) is one of the most common types of chronic glomerulonephritis, but the definite etiology and pathogenesis of IgAN are still unclear. IgAN is related to a variety of potential mechanisms, among which mucosal immune response is one of the important pathogenic factors. However, IgA protease and cytokines produced by microorganisms can cause corresponding histological changes via immune pathways. At present, the microbial diversity is considered to be closely related to the efficacy of clinical treatment and prognosis of IgAN. With the increasing researches on related pathogenic mechanisms, the clinical data of IgAN treatment have been on the rise as well. Therefore, exploring the microbe-related immune mechanisms in IgAN is of great significance for the effective treatment of IgAN.