血栓调节蛋白抑制慢性肾脏病微炎症的机制研究进展*

Mechanisms of thrombomodulin inhibiting micro-inflammation in chronic kidney disease*

摘要:

慢性肾脏病患者体内普遍存在一种微炎症状态，这种持续存在的炎症状态会进一步加重肾脏损 伤。如何改善慢性肾脏病患者的微炎症状态是当今国内外研究关注的热点之一。而与肾脏血管内皮受损密切 相关的血栓调节蛋白是调控体内多种生理反应的关键位点，具有抗凝、抗炎、保护内皮细胞及维持血管稳态 的功能，可为慢性肾脏病抗炎治疗提供新的思路。因此，该文就血栓调节蛋白抑制慢性肾脏病微炎症的机制 展开综述。

关键词:肾病;慢性病;血栓调节蛋白;炎症

Abstract:

A state of micro-inflammation is common in patients with chronic kidney disease, and the persistent presence of micro-inflammation can further aggravate renal damage. How to improve the microinflammatory state of chronic kidney disease patients is one of the hot spots of research at home and abroad. Thrombomodulin, which is closely related to the damage of renal vascular endothelium, is the key to regulating various physiological reactions, and plays a role in anticoagulation, anti-inflammation, endothelial cell protection and vascular homeostasis maintenance, providing a new target for the anti-inflammatory treatment of chronic kidney disease. Therefore, this article reviews the mechanisms of thrombomodulin inhibiting micro-inflammation in chronic kidney disease.

Key words:thrombomodulin; chronic kidney disease; micro-inflammation