清肺祛瘀汤联合信必可都保治疗对支气管哮喘患者血清IgE、肺功能的影响

Effect of Qingfei Quyu decoction combined with budesonide and formoterol fumarate powder for inhalation on serum IgE and pulmonary function improvement in patients with bronchial asthma

摘要:

目的 探讨清肺祛瘀汤联合信必可都保对支气管哮喘患者的临床疗效，以及对患者血清IgE、肺功能的影响。方法 选取2016年4月1日—2018年6月5日武汉理工大学医院收治的119例支气管哮喘患者，分为对照组59例和观察组60例。对照组采用信必可都保进行治疗，观察组采用清肺祛瘀汤联合信必可都保进行治疗。比较两组患者治疗后临床疗效、中医证候积分、哮喘ACT评分、血清IgE水平及肺功能。结果 观察组治疗总有效率（93.33%）高于对照组（79.66%）（P <0.05）；治疗后两组的血清IgE水平、中医证候积分均下降（P <0.05）；治疗后观察组的血清 IgE 水平、中医证候积分低于对照组（P <0.05）；治疗后两组哮喘控制ACT评分、第1秒用力呼气量（FEV1）、第1秒用力呼气量与用力肺活量比值（FEV1%）、呼气峰值流速（PEF）较治疗前上升（P <0.05）；治疗后观察组的ACT评分、FEV1、FEV1%及PEF高于对照组（P <0.05）。结论 清肺祛瘀汤联合信必可都保治疗对支气管哮喘患者临床疗效确切，能有效缓解患者症状，降低血清IgE水平，减少气道炎症，改善肺功能。

Abstract:

Objective To investigate the efficacy of Qingfei Quyu decoction combined with budesonide and formoterol fumarate powder for inhalation on serum IgE and lung function in patients with bronchial asthma Methods Totally 119 patients with bronchial asthma admitted to the respiratory department of Wuhan University of Technology Hospital from April 1, 2016 to June 5, 2018 were selected and divided into control group (59 cases) and observation group (60 cases). The control group was treated with xinbikedubao inhalation; the observation group was treated with Qingfei Quyu decoction combined with xinbikedubao inhalation. The clinical efficacy, TCM syndrome score, asthma act score, serum IgE level, and lung function were compared between the two groups. Results The total effective rate of the observation group after treatment was significantly higher than that of the control group (93.33% VS. 79.66%, P < 0.05). The TCM syndrome scores and serum IgE levels of the two groups were decreased after treatment (P < 0.05), and the decrease of the observation group was more significant (P < 0.05). The ACT scores of cough and asthma control, FEV1, FEV1/FVC, and PEF levels were increased in both groups after treatment (P < 0.05), and the increase in the observation group was more significant (P < 0.05). Conclusions Qingfei Quyu decoction combined with budesonide and formoterol fumarate powder for inhalation is effective in patients with bronchial asthma, which can effectively relieve symptoms and signs, decrease serum IgE levels, reduce airway inflammation, and improve lung function.