内皮祖细胞在急性肺损伤中应用的研究进展*

Research progress on application of endothelial progenitor cells in acute lung injury*

摘要:

急性肺损伤是由各种肺内外因素导致的进行性呼吸困难和难治性低氧血症，其病理特征包括炎 症反应及肺泡-毛细血管屏障功能破坏，微循环血管内皮损伤是主要标志。内皮祖细胞可以从骨髓动员迁移 到损伤部位，分化为成熟内皮细胞发挥直接修复作用，并通过间接免疫调节作用改善微环境。此外内皮祖细 胞还可以分泌细胞因子以自分泌或旁分泌方式促进新生血管生成从而减少器官功能障碍。文章旨在综述内皮 祖细胞在急性肺损伤中的应用，从而为治疗急性肺损伤提供新思路。

Abstract:

ALI (Acute lung injury, ALI) is an acute progressive dyspnea and refractory hypoxemia caused by a variety of internal and external pulmonary factors. Inflammation and destruction of alveolar-capillary barrier are the main pathological characters of ALI, in which endothelial injury of microcirculation is the hallmark. Mobilizing from bone marrow, EPC (endothelial progenitor cell, EPC) can migrate towards the sites of vascular injuries and differentiate into mature endothelium to play a direct repair role and improve microenvironment through indirect immunomodulation. In addition , EPC also secrete cytokines that promote angiogenesis in an autocrine or paracrine manner. Thereby, alleviating organ dysfunction. This article is dedicated to describe the application of EPC in ALI to provide new insight for treatment of ALI.