Omega-3多不饱和脂肪酸对脓毒症相关肠道菌群失调的治疗潜力*

Therapeutic potential of omega-3 polyunsaturated fatty acids in alleviating sepsis-related intestinal microbial dysbiosis*

摘要:

多样化的肠道菌群正常状态下可以增强宿主防御能力，但在脓毒症状态下，肠道菌群易受到干 扰而失调，导致患者预后不佳。如何通过改善肠道菌群失调从而提高脓毒症患者的生存率越来越受到关注。 Omega-3多不饱和脂肪酸因具有免疫调节、抗炎等作用，成为诸多脓毒症治疗研究的焦点。该文介绍了脓 毒症相关肠道菌群失调的特征，以及Omega-3多不饱和脂肪酸对脓毒症相关肠道菌群失调的治疗潜力，为 改善脓毒症治疗提供新视角。

Abstract:

Under physiologic conditions, diverse intestinal flora might enhance host responses against invading pathogens. However, intestinal flora might be disturbed and collapsed in sepsis which will result in poor prognosis. How to alleviate the intestinal flora dysbiosis and therefore to improve the survival rate of patients with sepsis has drawn growing attention. Omega-3 polyunsaturated fatty acids have become one of the research highlights due to their immunomodulatory and anti-inflammatory effects. This article mainly reviews the characteristics of sepsis-related intestinal microbial dysbiosis and possible roles of omega-3 polyunsaturated fatty acids in ameliorating sepsis-related intestinal microbial dysbiosis, in order to provide a new insight into the treatment of sepsis.