NLRP3炎症小体对口腔鳞状细胞癌作用的研究进展*

Advances on the role of NLRP3 inflammasome in oral squamous cell carcinoma*

摘要:

慢性炎症在肿瘤的进展过程中发挥着重要作用，NLRP3炎症小体作为NLRs家族的核心蛋白， 其激活后可以招募ASC，裂解Caspase-1并使其活化，促进IL-1β和IL-18分泌成熟，进而介导炎症反应。 目前，关于NLRP3炎症小体的研究较为深入，其与体内炎症、肿瘤等多种疾病的发生、发展密切相关。该 文针对NLRP3炎症小体对口腔鳞状细胞癌的相关作用进行综述。

Abstract:

Chronic inflammation plays an important role in the progression of tumors. The NLR family pyrin domain containing 3 (NLRP3) inflammasome, the core protein of the NOD-like receptors (NLRs) family, recruits apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC) after its activation, and then cleaves caspase-1 to activate it, thereby promoting the maturation of interleukin-1β (IL-1β) and interleukin-18 (IL18), which further mediates the inflammatory response. At present, NLRP3 inflammasome is studied deeply, and it has been demonstrated to be closely related to the occurrence and development of various diseases such as inflammation and cancer. However, the overview of the role of NLRP3 inflammasome in oral squamous cell carcinoma has not been reported. This article will review the relevant effects of NLRP3 inflammasome on oral squamous cell carcinoma.