CD10、CD133 和CD157 在胃癌组织中的表达及其临床意义
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Expression and clinical significance of CD10, CD133 and CD157 in gastric cancer
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    摘要:

    目的 探讨CD10、CD133和CD157在胃癌组织中的表达及其临床意义。方法 选取2016年3月— 2019年3月在义乌市中心医院行手术治疗患者的胃癌组织标本105例,并取距肿瘤边缘≥5 cm的正常组织作为癌旁 组织。采用免疫组织化学染色法测定癌组织和癌旁组织中CD10、CD133 和CD157 蛋白的表达。随访至 2020 年9 月30 日,以患者死亡作为随访终点事件,计算患者总生存期。结果 癌组织CD10、CD133 和 CD157 蛋白表达阳性率均高于癌旁组织(P <0.05)。CD10、CD133 和CD157 蛋白表达阳性患者累积生存率 优于阴性患者(P <0.05)。年龄[R^R=1.628 (95% CI:1.218,2.940)]、临床分期[R^R=1.982 (95% CI: 1.435,3.495)]、浸润深度[R^R=2.653 (95% CI:1.782,4.213)]、淋巴结转移[R^R=3.287 (95% CI: 1.989,5.456)]、CD10 阳性表达[R^R=2.081 (95% CI:1.297,3.241)]、CD133 阳性表达[R^R=1.768 (95% CI:1.190,2.879)] 和CD157 阳性表达[R^R=2.463 (95% CI:1.797,4.165)] 是影响胃癌患者预 后的独立危险因素。结论 CD10、CD133 和CD157 在胃癌组织中高表达,且与淋巴结转移和预后密切相关。

    Abstract:

    Objective To investigate the expression and clinical significance of CD10, CD133 and CD157 in gastric cancer. Methods We selected 105 cases of gastric cancer tissue samples surgically removed in Yiwu Central Hospital from March 2016 to March 2019, and adjacent normal tissues ≥5cm away from the edge of the tumor were taken as control samples. The expression of CD10, CD133 and CD157 protein in cancer tissues and adjacent normal tissues was detected by immunohistochemical staining. The patients were followed up until September 30, 2020. The death of the patients was taken as the endpoint event, and the overall survival (OS) was calculated. Results The positive rates of CD10, CD133 and CD157 protein expression in cancer tissues were higher than those in adjacent normal tissues (P < 0.05). The OS of patients with positive expression of CD10, CD133 and CD157 was better than that of patients with negative expression of these molecules (P < 0.05). Age [R^R = 1.628 (95% CI: 1.218, 2.940)], TNM stage [R^R = 1.982 (95% CI: 1.435, 3.495)], depth of invasion [R^R = 2.653 (95% CI: 1.782, 4.213)], lymph node metastasis [R^R = 3.287 (95% CI: 1.989, 5.456)], positive expression of CD10 [R^R = 2.081 (95% CI: 1.297, 3.241)], positive expression of CD133 [R^R = 1.768 (95% CI: 1.190, 2.879)] and positive expression of CD157 [R^R = 2.463 (95% CI: 1.797, 4.165)] were independent risk predictors of gastric cancer (P < 0.05). Conclusion The CD10, CD133 and CD157 are highly expressed in gastric cancer, and closely related to lymph node metastasis and prognosis.

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郑国强,朱献斐. CD10、CD133 和CD157 在胃癌组织中的表达及其临床意义[J].中国现代医学杂志,2021,(6):16-22

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  • 收稿日期:2021-01-06
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