趋化因子受体7联合CT诊断膀胱移行细胞癌淋巴结转移

Chemokine receptor CCR7 as a predictive biomarker associated with computed tomography in diagnosing lymph node metastasis of bladder carcinoma

摘要:

目的 研究膀胱移行细胞癌（BTCC）中趋化因子受体7（CCR7）的表达，并联合CT诊断淋巴结转移。方法 研究该院行根治性膀胱全切+盆腔淋巴结清扫的115例病例，术前行泌尿系及盆腔CT扫描，膀胱癌组织标本行CCR7免疫组织化学染色并记录盆腔淋巴结转移情况。运用统计学方法分析CCR7的表达与淋巴结转移的关系，并比较分析CCR7、CT及CCR7联合CT诊断膀胱癌淋巴结转移的敏感性、特异性和精确度。结果 BTCC组织中的CCR7表达与淋巴结转移相关（P <0.05）。多因素分析显示CCR7的表达是膀胱癌淋巴结转移的独立影响因子（P <0.05）。采用CT诊断淋巴结转移的敏感性、特异性和精确度分别为52.4%、79.5%及69.6%，而CCR7联合CT诊断淋巴结转移的敏感性、特异性和精确度分别为92.3%、83.6%及70.0%。结论 CCR7是膀胱癌淋巴结转移的独立影响因子，CCR7联合CT可提高CT诊断淋巴结转移的敏感性。

Abstract:

【Objective】 To determine whether chemokine receptor CCR7 expression combined with computed tomography (CT) has a relationship with lymph node metastasis in bladder transitional cell carcinoma (BTCC). 【Methods】 Totally 115 BTCC cases were studied in our department. Preoperative CT scans of abdomen and pelvis, CCR7 immunohistochemical expression in tumor specimens and pathological findings for lymph node metastasis were assessed. The sensitivity, specificity and accuracy of CCR7, CT and their combination in diagnosis of lymph node metastasis of BTCC were evaluated. 【Results】 The CCR7 expression in BTCC was correlated with lymph node metastasis (P < 0.05). Multivariate analysis indicated that CCR7 expression was an independent predictor for lymph node metastasis in BTCC (P < 0.05). The sensitivity, specificity and accuracy of CCR7 combined with CT scan in the diagnosis of lymph node metastasis of BTCC were 92.3%, 83.6% and 70.0%, respectively; those of CT alone were 52.4%, 79.5% and 69.6%, respectively. 【Conclusions】 CCR7 is an independent indicator for lymph node metastasis of BTCC. CCR7 combined with CT can improve the sensitivity of CT in diagnosing lymph node metastasis in BTCC.