人G补缀FHA域血管生成因子1在宫颈癌组织中的表达及其临床意义

AGGF1 expression in cervical carcinoma and its association with clinicopathological variables

摘要:

 探索人G补缀FHA域血管生成因子1（AGGF1）在宫颈癌中的表达及与宫颈癌患者预后的相关性。方法  对60例宫颈癌组织及癌旁组织进行AGGF1免疫组织化学法检测，并对其表达及与患者预后的相关性进行分析。结果  AGGF1在宫颈癌组织中的表达比癌旁组织高（P <0.05），Kaplan-meier曲线分析发现，AGGF1表达高的患者生存较差（P =0.004）。Cox回归模型分析发现，AGGF1可以作为独立指标预测宫颈癌患者术后生存。结论  宫颈癌患者AGGF1高表达预示预后较差，并且其可以作为一个独立因素来预测宫颈癌患者术后生存。

关键词:

AGGF1;免疫组织化学法;宫颈癌;预后

Abstract:

 Objective To determinethe expression of human angiogenic factor with G patch and FHA domains 1 (AGGF1) in cervical carcinoma, and to investigate its relationship with the prognosis of cervical carcinoma. Methods Immunohistochemistry was performed to detect AGGF1 level in the cervical cancer tissues and pericancerous tissues of 60 cases, and the relationship between the expression of AGGF1 and prognosis of the patients was analyzed. Results The expression of AGGF1 in the cervical carcinoma tissues was significantly higher than that in the pericancerous tissues (P < 0.05). The survival rate of the patients with high AGGF1-expression was significantly lower than that of the patients with low AGGF1-expression (P = 0.004). The Cox model analysis revealed that AGGF1 expression was an independent biomarker for prediction of the survival of cervical carcinoma patients. Conclusions High expression of AGGF1 predicts poor prognosis in cervical carcinoma patients. AGGF1 can be used as an independent factor to predict postoperative survival of patients with cervical cancer.

Key words:

 ;angiogenic factor with G patch and FHA domains 1; IHC; cervical carcinoma; prognosis