胸腺肽α1和乌司他丁对急性颅脑损伤患者的免疫调理作用

Immunomodulation of thymosin α 1 and Ulinastatin in patients with acute brain trauma

摘要:

目的  探讨胸腺肽α1和乌司他丁（UTI）对急性颅脑损伤患者的免疫调理作用。方法  将50例急性颅脑损伤患者随机分为对照组和治疗组，对照组予以常规治疗方案；治疗组除常规治疗方案外，同时接受胸腺肽α1及UTI免疫调理治疗。另选取25例健康人作为正常组，并于治疗后1、3、7和14 d取血，检测血清中炎症细胞因子[白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、IL-10、TGF-β1]和细胞免疫指标[CD4+、CD8+、CD4+/CD8+、CD14+单核细胞人白细胞DR抗原（HLA-DR）]的水平。结果  在治疗3、7和14 d后，对照组和治疗组血液中IL-6、TNF-α、IL-10、TGF-β1水平升高，CD4+、CD8+、CD4+/CD8+水平降低，与正常组比较，差异有统计学意义（P <0.05）；治疗组血液中IL-6、TNF-α水平降低，IL-10、TGF-β1水平升高；CD4+、CD8+和HLA-DR水平升高，与对照组比较，差异有统计学意义（P <0.05），同时CD4+/CD8+水平也不同程度改善。结论  胸腺肽α1和UTI对急性颅脑损伤患者有较好的免疫调理作用。

Abstract:

Objective To observe the immunomodulation of thymosin α1 and Ulinastatin on acute brain trauma. Methods Fifty patients with acute brain trauma were selected and randomly divided into control group and experimental group. The control group was treated according to the conventional treatment plan, and the experimental group was given thymosin α1 and Ulinastatin besides the conventional treatment. Twenty-five healthy people were selected into normal group. Blood was taken 1, 3, 7 and 14 days after treatment. Serum  levels of inflammatory cytokines (IL-6, TNF-α, IL-10 and TGF-β1) and cellular immune parameters (CD8+, CD4+, CD4+/CD8+, CD14+ HLA-DR) were detected. Results After treatment for 1, 3, 7 and 14 days, serum IL-6, IL-10, TNF-α and TGF-β1 significantly increased; CD4+, CD8+ and CD4+/CD8+ significantly decreased in the control and experimental groups compared with the normal group (P < 0.05); serum IL-6 and TNF-α significantly decreased while IL-10, TGF-β1, CD4+, CD8+ and HLA-DR remarkably increased in the experimental group compared with the control group (P < 0.05); at the same time, CD4+/CD8+ had a different degree of improvement. Conclusions Thymosin α1 and Ulinastatin have immune regulatory effect on the patients with acute brain trauma.