自拟醒窍益气汤联合穴位针刺治疗过敏性鼻炎的疗效探讨

Clinical effects of self-made Xingqiao Yiqi Decoction combined with acupuncture in treatment of allergic rhinitis

摘要:

目的  探讨自拟醒窍益气汤联合穴位针刺治疗过敏性鼻炎的临床效果。方法  选择该院耳鼻喉科2012年5月-2014年12月收治的过敏性鼻炎患者170例，采用随机区组法分为对照组（85例）和中西医结合组（85例），分别给予氯雷他定单用和在此基础上加用自拟醒窍益气汤联合穴位针刺治疗，比较两组患者临床疗效，治疗前后鼻部症状体征积分、最大呼气流速（PEF）、PEF昼夜变异率、IgE、肿瘤坏死因子-α（TNF-α）、白介素-4
（IL-4）、IL-12水平及临床复发率等。结果  中西医结合组患者临床疗效优于对照组，差异有统计学意义（P <
0.05）；中西医结合组患者治疗后鼻部症状体征积分低于对照组、治疗前，差异有统计学意义（P <0.05）；中西医结合组患者治疗后PEF和PEF昼夜变异率水平优于对照组、治疗前，差异有统计学意义（P <0.05）；中西医结合组患者治疗后IgE、TNF-α、IL-4及IL-12水平优于对照组、治疗前，差异有统计学意义（P <0.05）；中西医结合组患者临床复发率低于对照组，差异有统计学意义（P <0.05）。结论  自拟醒窍益气汤联合穴位针刺治疗过敏性鼻炎可显著减轻临床症状和体征，改善鼻部通气功能，控制炎症反应水平，并有助于降低复发风险。

Abstract:

Objective To investigate clinical effects of self-made Xingqiao Yiqi Decoction combined with acupuncture in the treatment of allergic rhinitis. Methods Totally 170 patients with allergic rhinitis were chosen in our hospital in the period from May 2012 to December 2014, and randomly divided into two groups including control group (85 patients) with Loratadine used alone and TCM combined with Western medicine group (85 patients) with self-made Xingqiao Yiqi Decoction combined with acupuncture in addition to Loratadine. The clinical efficiency, the scores of nasal symptoms and signs, the levels of peak expiratory flow (PEF), PEF diurnal variation frequency, IgE, TNF-α, IL-4 and IL-12 before and after treatment and the clinical recurrence rate were compared between both groups. Results The clinical efficiency of the TCM combined with Western medicine group was significant higher than that of the control group (P < 0.05). The scores of nasal symptoms and signs of the TCM combined with Western medicine group after treatment was significantly better than those of the control group and before treatment (P < 0.05). The levels of PEF and PEF diurnal variation frequency of the TCM combined with Western medicine group after treatment were significantly better than those of the control group and before treatment (P < 0.05). The levels of IgE, TNF-α, IL-4 and IL-12 of the TCM combined with Western medicine group after treatment were significantly better than those of the control group and before treatment (P < 0.05). The clinical recurrence rate of the TCM combined with Western medicine group was significantly lower than that of the control group (P < 0.05). Conclusions Self-made Xingqiao Yiqi Decoction combined with acupuncture for the treatment of allergic rhinitis can efficiently relieve the clinical symptoms and signs, improve the nasal ventilation function, control the level of inflammation and is helpful in reducing the risk of recurrence.