T细胞亚群及PCT监测在学龄前儿童支原体肺炎诊治中的价值

Value of T cell subsets and PCT detection in diagnosis and treatment of Mycoplasma pneumonia in preschool children

摘要:

探讨T细胞亚群及降钙素原（PCT）监测在学龄前儿童支原体肺炎（MPP）诊治中的价值。方法选取该院收治的91例MPP患儿为研究对象（实验组），根据患儿是否合并细菌感染分为细菌感染组和单纯MPP组，以同期幼儿园体检正常的61 例儿童为对照组。实验组患儿随临床治疗，动态监测T 淋巴细胞亚群和PCT水平，比较各组的结果。结果比较单纯MPP 组和细菌感染组疗效：单纯MPP组的TCD4+和PCT 指标比细菌感染组变化较大，差异有统计学意义（p <0.05），两组其余指标的差值比较，差异无统计学意义（p >0.05）；治疗后两实验组与对照组比较，TCD4+、TCD8+及TCD4+/TCD8+ 3 项指标差异无统计学意义（p >0.05），而细菌感染组的PCT指标仍高于对照组及单纯MPP组患儿，差异有统计学意义（p <0.05）。结论TCD4+和PCT水平监测在MPP及合并细菌感染患儿的诊治中有一定的指导意义。

Abstract:

To explore the value of T cell subsets and procalcitonin (PCT) monitoring in the diagnosis and treatment of Mycoplasma pneumonia (MPP) in preschool children. Methods Ninety-one children with MPP in our hospital were selected as the research objects (experimental group) and divided into combined bacterial infection group and simple MPP group according to whether the patients had bacterial infection, 61 children with normal physical examination in the same period were selected as the healthy control group. T lymphocyte subsets and PCT levels were dynamically monitored during clinical treatment, the differences were compared among the groups. Results The proportion of CD4+ T cells and PCT level in the MPP group were significantly higher than those in the combined infection group (p <0.05). After treatment, there was no significant difference in CD4+ T cells, CD8+ T cells or CD4+ T cells / CD8+ T cells ratio between the two experimental groups and the control group (p > 0.05). However, the PCT level of the combined infection group was still significantly higher than that of the control group and the MPP group (p < 0.05). Conclusions CD4+T cells and PCT level monitoring has certain guiding significance in the diagnosis and treatment of patients with MPP and merger of bacterial infection.