炎症性肠病患者幽门螺杆菌感染情况研究

Helicobacter pylori infection in patients with inflammatory bowel diseases

摘要:

摘要：目的  探讨幽门螺杆菌（Hp）感染与炎症性肠病（IBD）的关系。方法  选取2003年1月-2015年12月在大连医科大学附属第一医院住院并明确诊断为溃疡性结肠炎（UC）或克罗恩病（CD）的患者165例，及相同例数同期入院的慢性胃炎患者为对照组，通过胃镜下快速尿素酶试验方法检测Hp感染情况，比较两组幽门螺旋杆菌感染率有无差异。结果  UC患者149例（男性70例），CD患者16例（男性9例）。UC组和CD组患者Hp感染率与对照组比较，差异有统计学意义（P <0.05）。CD组与UC组Hp感染率比较，差异有统计学意义（P <0.05）。E1组（病变范围为直肠）Hp感染感染率与E2组（病变范围为左半结肠）比较，差异无统计学意义（P >0.05），E3组（病变范围为广泛结肠及全结肠）Hp感染率与E1、E2组比较，差异有统计学意义（P <0.05）。结论  IBD患者Hp感染率较慢性胃炎患者低，但仍处于较高水平。CD组较UC组Hp感染率低，UC患者中全结肠受累患者HP感染率比部分结肠受累者低，HP感染可能对IBD的发生起保护作用。

Abstract:

Abstract: Objective To investigate the relationships between Helicobacter pylori infection and inflammatory bowel diseases. Methods From January 2003 to December 2015, 165 patients diagnosed as ulcerative colitis (UC) or Crohn's disease (CD) were enrolled in the First Affiliated Hospital of Dalian Medical University, 165 hospitalized patients of chronic gastritis during the same period were enrolled as controls. All the patients received rapid urea test by endoscopy to detect Helicobacter pylori infection. The Helicobacter pylori infection rates of these two groups were analyzed statistically. Results There were 149 cases of UC patients (70 male cases) and 16 patients with CD (9 male cases). There were significant differences in Helicobacter pylori infection rates between the control group and both the UC and CD groups (P < 0.05). And the Helicobacter pylori infection rate of the CD patients was lower than that of the UC patients (P < 0.05). Moreover, the Helicobacter pylori infection rate in the E1 group (lesions in the rectum) and the E2 group (lesions in the left colon) had no significant difference (P > 0.05). But the Helicobacter pylori infection rate in the E3 group (lesions in extensive or complete colon) was lower than those in the E1 and E2 groups (P < 0.05). Conclusions Helicobacter pylori infection rates in the patients with inflammatory bowel diseases are lower than that in the patients with chronic gastritis, but still at a high level. Helicobacter pylori infection rate in the patients with CD is lower than that in the patients with UC. Helicobacter pylori infection rate in the UC patients with pan-colon involvement is lower than that in the UC patients with rectum or left colon involvement. Helicobacter pyloriinfection may be a protective factor in the patients with inflammatory bowel diseases.