Abstract:Objective To explore current situation and influence factors of self-medication in urban and rural children, and to provide evidence for relevant strategy-making. Methods A survey was conducted in urban and rural areas of Xinxiang City, and the interception survey was used for females over the age of 18. Epidata 3.0 software was used to input data, the SAS 9.2 software was applied for data statistical analysis. The relevant characters of selfmedication in the three areas were described by counting and proportion. Chi square test was used in the comparative analysis of the three areas. The factors influencing the cognitive scores were analyzed by multi-factor logistic regression analysis. Results A total of 1,045 valid questionnaires were collected from the families with children. As a result, 84.90% of residents in the city, 88.00% in the county and 88.65% in the rural areas had experience of self-medication for children. The major reason for children self -medication was that the cases'condition was mild, accounting for 53.27%, 57.40% and 60.16% of the three regions respectively. The medication was mainly based on their own experience, accounting for 56.25%, 54.21% and 40.65% in the city, county and rural areas. Prior to children taking drugs, lots of parents did not often read instructions for users (Urban: 29.12%; County: 37.13%; Rural: 39.34%), and the differences among the three areas were not statistical significant (x2 = 8.0625,P =0.089). There were significant differences in the on-time medication for children, and the measures when forgot to give children medicine among the three regions. The urban and rural areas, education level, occupation, health status and family income were related to the cognitive scores of self-medication behavior. Conclusions The rate of children self-medication is high in urban and rural areas. Safety self-medication behavior and cognition of children are related with urban and rural areas, education degree, occupation, health status, and family monthly income. The government should conduct relevant health education for people in different regions and different populations.