SOCS2、SOCS5 在儿童过敏性紫癜中的表达及其意义

Expressions of SOCS2 and SOCS5 in children with allergic purpura and their clinical significance

摘要:

目的 探讨细胞因子信号传导抑制蛋白2（SOCS2）和SOCS5 在儿童过敏性紫癜（HSP）中的表达及其意义。方法 应用逆转录聚合酶链反应检测HSP 患儿（36 例）和正常健康对照儿童（17 例）外周血单个核细胞中SOCS2 和SOCS5 mRNA 表达水平。结果 HSP 患儿SOCS2 和SOCS5 mRNA 表达水平高于对照儿童（P <0.05）。混合型HSP 患儿SOCS2 和SOCS5 mRNA 表达水平较单纯型患儿升高（P <0.05）。HSP 患儿SOCS2 和SOCS5 mRNA 表达水平无性别差异（P >0.05）。结论 SOCS2、SOCS5 可能参与儿童HSP 的发病。

Abstract:

Objective To explore the expression and clinical significance of suppressor of cytokine signaling 2 (SOCS2) and SOCS5 in children with Henoch-Schoenlein purpura (HSP) by detecting the levels of SOCS2 and SOCS5 mRNAs. Methods RT-PCR was used to detect the expressions of SOCS2 and SOCS5 mRNAs in peripheral blood mononuclear cells (PBMC) from children with HSP (HSP group, n = 36) and healthy children (control group,n = 17) respectively. Results The mRNA levels of SOCS2 and SOCS5 were up-regulated in the HSP group as compared with the control group (P < 0.05). The expression levels of SOCS2 mRNA and SOCS5 mRNA in the children with mixed type HSP were significantly higher than those in the children with simple type HSP, and the differences were statistically significant (P < 0.05). The expression levels of SOCS2 mRNA and SOCS5 mRNA had no difference in the gender of the HSP children (P > 0.05). Conclusions SOCS2 and SOCS5 may participate in the pathogenesis of HSP in children.