疏肝活血法联合窄谱中波紫外光治疗气滞血瘀型白癜风的疗效观察

Narrow-band UVB combined with Liver-discharging and Bloodactivating Decoction for treatment of vitiligo due to Qi-stagnation and blood-stasis

摘要:

目的 观察口服疏肝活血中药联合窄谱中波紫外线照射治疗气滞血瘀型白癜风方面的疗效和安全性。方法 将90 例白癜风患者随机分为联合组、光疗组及中药组，每组各30 例。联合组口服该院舒肝活血中药配方颗粒，2 次/d。并且用311 nm 窄谱中波紫外光照射治疗，每周照射1、2 次。光疗组：照射311 nm 窄谱中波紫外光，每周照射1、2 次。中药组：口服该院疏肝活血中药配方颗粒，2 次/d。每3 个月进行1 次白癜风白斑复色率疗效评价、中医证候评分改善疗效评价及肝肾功能评测。共观察3 个疗程。结果联合组白斑疗效总有效率均高于光疗组和中药组（P <0.05）；疗效与患者白斑部位、病程有相关性，与患者年龄无相关性；联合组中医证候改善总有效率均高于光疗组，与中药组无差异（P >0.05）。结论 应用疏肝活血法联合窄谱中波紫外光治疗气滞血瘀型白癜风能获得满意疗效，可在临床推广应用。

Abstract:

Objective To observe the clinical efficacy and security of treating vitiligo caused by stagnation of Qi and blood stasis with the narrow-band UVB combined with Liver-discharging and Blood-activating Decoction. Methods The selected 90 cases of vitiligo were randomly divided into three groups. Combined group included 30 patients with 53 lesions. In either ultraviolet treatment group or traditional Chinese medicine group there were 30 patients with 42 lesions. The patients in the combined group received 311 nm narrow-band UVB therapy once or twice a week combined with oral Liver-discharging and Blood-activating Decoction twice a day. The patients in the ultraviolet treatment group received 311 nm narrow-band UVB therapy once or twice a week. And the patients in the traditional Chinese medicine group received oral Liver-discharging and Blood-activating Decoction twice a day.The curative effect was evaluated once every three months (a course of treatment) through the color-recovery rate of white spots, TCM syndrome improvement score, and liver and kidney function evaluation. The observation lasted for three courses of treatment. Results The total effective rate of the combined group was significantly higher than that of other two groups after completion of each treatment course. The curative effect was related to vitiligo part of skin lesions and course of the disease, but not correlated with age. After three courses of treatment, the TCM syndrome was improved. The total effective rate of the TCM syndrome improvement in the combined group was higher than that in the ultraviolet treatment group but was not statistically different from that in the traditional Chinese medicine group. Conclusions Joint application of Liver-discharging and Blood-activating and narrow-band UVB could get satisfactory effect in the treatment of vitiligo due to Qi-stagnation and blood-stasis. It can be popularized in clinical application.