中性粒细胞/淋巴细胞比值与2型糖尿病肾病的相关性探讨

Correlation between neutrophil to lymphocyte ratio and type 2 diabetic nephropathy

摘要:

目的探究中性粒细胞/ 淋巴细胞比值（NLR）与2 型糖尿病肾病的相关性。方法回顾性分析2010 年1 月-2015 年12 月该院的2 型糖尿病肾病患者306 例患者的临床资料，分析中性粒细胞/ 淋巴细胞比值、年龄、性别、病程、体重指数、白细胞计数、中性粒细胞数、淋巴细胞计数、血肌酐、血尿素氮、血尿酸、空腹血糖、糖化血红蛋白、总胆固醇、三酰甘油、低密度脂蛋白、高密度脂蛋白等指标和2 型糖尿病肾病的相关性。结果Person相关性分析显示NLR和24 h微量白蛋白尿呈正相关（r =0.868，p =0.012），Logistic回归分析显示NLR是2 型糖尿病肾病的危险因素[OR =2.955，（95%CI：1.445，3.854），p =0.022]。结论NLR 是2 型糖尿病肾病的危险因素，临床工作中应重视NLR 异常变化的2 型糖尿病患者。

Abstract:

Objective To explore the relationship between neutrophil to lymphocyte ratio (NLR) and type 2 diabetic nephropathy. Methods In this case-control study, the clinical data of 306 adult patients with type 2 diabetic nephropathy in our hospital from January 2010 to December 2015 were retrospectively analyzed. Then, the correlations of type 2 diabetic nephropathy with NLR, age, sex, duration of the disease, BMI, WBC count, neutrophil count, lymphocyte count, serum creatinine, blood urea nitrogen, serum uric acid, fasting blood glucose, glycosylated hemoglobin, total cholesterol, triglyceride, low -density lipoprotein and high -density lipoprotein were analyzed. Results Person correlation analysis showed that NLR was positively related with microalbuminuria (r = 0.868,p =0.012). Logistic regression analysis showed that NLR was a risk factor of type 2 diabetic nephropathy [OR = 2.955(95% CI: 1.445, 3.854),p = 0.022]. Conclusions High NLR is closely related to type 2 diabetic nephropathy. Clinical doctors should pay attention to type 2 diabetic patients with a high NLR.