T2DM 患者血浆Gas6、Omentin-1 与IR、肥胖及脂代谢的相关性分析

Correlations of serum Gas6 and Omentin-1 with insulin resistance and lipid metabolism in type 2 diabetes patients

摘要:

目的 探讨2 型糖尿病（T2DM）患者血浆生长停滞特异性蛋白（Gas6）和网膜素-1（Omentin-1）与胰岛素抵抗（IR）、肥胖及脂代谢的相关性。方法 选择超重肥胖T2DM 患者[ 体重指数（BMI）≥25 kg/m2]40 例，体重正常T2DM 患者50 例，健康体检者30 例，应用酶联免疫吸附法测定3 组血浆Gas6、Omentin-1 水平，同时检测空腹胰岛素、空腹血糖及血脂，比较之间相关性。结果 T2DM 患者血浆Gas6、Omentin-1 水平降低，超重肥胖组低于体重正常组和对照组（P <0.05）。Gas6 和Omentin-1 水平与稳态模型 胰岛素抵抗指数、BMI、甘油三脂、胆固醇及低密度脂蛋白胆固醇呈负相关（P <0.05），与高密度脂蛋白胆固醇、胰岛素分泌指数呈正相关（P <0.05）。结论 T2DM 患者的血浆Gas6、Omentin-1 水平变化与IR、肥胖及脂代谢相关，可作为T2DM 预测指标。

Abstract:

Objective To investigate plasma growth arrest-specific 6 (Gas6) and Omentin-1 levels of type 2 diabetes patients and to explore the relationships of plasma Gas6 and Omentin-1 levels with insulin resistance (IR),obesity and lipid metabolism. Methods The fasting plasma levels of Omentin-1 and Gas6 were detected by enzymelinked immunosorbent assay (ELISA) in 40 T2DM patients with overweight obesity (BMI ≥ 25 kg/m2), 50 T2DM patients with normal weight and 30 normal controls. Meanwhile, data including fasting insulin (Fins), blood glucose and blood lipids were also obtained. The correlations of plasma Gas6 and Omentin-1 levels with those indicators were analyzed. Results Compared with the normal control group, the plasma levels of Gas6 and Omentin-1 were lower in the type 2 diabetes patients (P < 0.05). The plasma Gas6 and Omentin-1 levels of the overweight obesity group were significantly lower than those in the normal weight group and the normal control group (P < 0.05). The serum Gas6 and Omentin-1 levels were positively correlated with HDL-C (P < 0.05), but negatively correlated with HOMA-IR, BMI, TG, TC and LDL-C (P < 0.05). Conclusions The levels of plasma Gas6 and Omentin-1 are associated with insulin resistance, obesity and lipid metabolism, which may contribute to the pathogenesis of type 2 diabetes.BMI, TG, TC and LDL-C (P < 0.05). Conclusions The levels of plasma Gas6 and Omentin-1 are associated with insulin resistance, obesity and lipid metabolism, which may contribute to the pathogenesis of type 2 diabetes.BMI, TG, TC and LDL-C (P < 0.05). Conclusions The levels of plasma Gas6 and Omentin-1 are associated with insulin resistance, obesity and lipid metabolism, which may contribute to the pathogenesis of type 2 diabetes.