卵泡黄素化周期与自然排卵周期行冻融胚胎移植的临床结局比较

Comparison of clinical outcomes of frozen-thawed embryo transfer in luteinized unrupture follicle cycle and natural cycle

摘要:

摘要：目的  分析比较在卵泡不破裂黄素化（LUF）周期和自然排卵周期中行冻融胚胎移植（FET）的临床结局。方法  回顾性分析2013年7月-2015年6月广西壮族自治区南宁市第二人民医院生殖医疗中心1 380个自然周期下FET的临床结局。按卵裂期胚胎和囊胚期胚胎分组，比较174个LUF周期和1 206个自然排卵周期在同样的黄体支持方案下行FET的患者LUF或排卵前1天雌二醇（E2）和促黄体生成激素（LH）、LUF日或排卵日内膜厚度、胚胎生化妊娠率、胚胎种植率、临床妊娠率和早期流产率。结果  卵裂期胚胎LUF组的LH[（33.78±16.20）mIU/ml]与自然排卵组[（39.69±17.18）mIU/ml]比较，差异有统计学意义（P <0.05），卵裂期胚胎LUF组的LH比自然排卵组低。囊胚期胚胎LUF组的LH[（32.84±17.91）mIU/ml]与自然排卵组的[（40.27±
17.28）mIU/ml]比较，差异有统计学意义（P <0.05），囊胚期胚胎LUF组的LH比自然排卵组低。而两组胚胎的LUF组与自然排卵组的内膜厚度、排卵前1天的E2、胚胎生化妊娠率、胚胎种植率、临床妊娠率及早期流产率比较，差异无统计学意义（P >0.05）。结论  FET周期中，LUF周期在适当黄体支持下可取得和自然排卵周期相似的妊娠结局。

Abstract:

Abstract: Objective To compare the clinical outcomes of frozen-thawed embryo transfer in luteinized unrupture follicle (LUF) cycle and the natural cycle. Methods Totally 1,380 natural cycles of frozen-thewed embryo transfer which were performed in the Reproductive Medical Center of the Second People's Hospital of Nanning, Guangxi from July 2013 to June 2015 were retrospectively analyzed. The 1,380 cycles, including 174 LUF cycles and 1,206 natural cycles, were divided into cleavage stage embryo group and blastocyst group. The levels of E2 and LH on the day before LUF or ovulation, endometrial thickness, biochemical pregnancy rate, implantation rate, clinical pregnancy rate and early abortion rate were compared. Results In the cleavage stage embryo group, the level of LH on the day before LUF was statistically lower than that on the day before ovulation [(33.78 ± 16.20) mIU/ml vs (39.69 ± 17.18) mIU/ml, P < 0.05]. Meanwhile, in the blastocyst group, the level of LH on the day before LUF was also statistically lower than that on the day before ovulation [(32.84 ± 17.91) mIU/ml vs (40.27 ± 17.28) mIU/ml, P < 0.05]. But there was no obvious statistical diffe-rence in endometrial thickness, biochemical pregnancy rate, implantation rate, clinical pregnancy rate or early abortion rate between the two groups (P > 0.05). Conclusions For frozen-thewed embryo transfer, LUF cycle with adequate luteal phase support can achieve a pregnancy outcome similar to the natural ovulation cycle.