系统性红斑狼疮患者25-（OH）D3和VD-Ab的致病作用及其临床意义

Pathogenic role and clinical significance of 25-hydroxy vitamin D3 and vitamin D antibodies in patients with systemic lupus erythematosus

摘要:

摘要：目的  观察25羟维生素D3[25-（OH）D3]和维生素D抗体（VD-Ab）水平在系统性红斑狼疮（SLE）患者中的致病作用。方法  选取2013年11月-2015年3月资料完整的SLE患者共90例作为病例组。选择同时期至本院进行体检的健康志愿者60例作为对照组，根据是否接受过维生素D及相关治疗将病例组患者分为治疗组和未治组，观察病例组与对照组的血清25-（OH）D3水平，治疗组与未治组血清25-（OH）D3水平，以及治疗组、未治组与对照组中血清VD-Ab水平比较。结果  病例组25-（OH）D3水平低于对照组。治疗组25-（OH）D3水平与未治组比较，差异无统计学意义（P >0.05）。随着活动度加重，25-（OH）D3水平逐渐降低，治疗组与未治组、未治组与对照组，治疗组与对照组间VD-Ab水平比较，差异无统计学意义（P >0.05）。结论  SLE患者25-（OH）D3水平降低与维生素D治疗无关。但是随着活动程度加重，25-（OH）D3水平逐渐降低。VD-Ab与维生素D水平无关。

关键词:

系统性红斑狼疮;25羟维生素D3;维生素D抗体

Abstract:

Abstract: Objective To observe the pathogenic role of 25-hydroxy vitamin D3 and vitamin D antibodies (VD-Ab) in patients with systemic lupus erythematosus(SLE). Methods The complete data of 90 SLE patients from November 2013 to March 2015 were set as the case group and divided into untreated group and treated group according to whether the patients accepted Vit D and relevant treatment, meanwhile 60 healthy volunteers having medical examination in the hospital during the same period of time were enrolled as control group. The serum 25-(OH) D3 and VD-Ab levels were observed and compared between the untreated and treated groups, the case group and control group. Results The serum 25-(OH) D3 level of the case group was significantly lower than taht of the control group. There was no statistically significant difference between serum 25-(OH) D3 levels of the untreated group and treated group (P > 0.05). As the active degree was aggravating, 25-(OH) D3 level gradually reduced, VD-Ab had no statistical differences between the untreated and treated groups, the untreated group and the control group, and the treated group and the control group (P >0.05). Conclusions Decrease of 25-(OH) D3 level in SLE patients is not associated with Vit D treatment. However as the active degree is aggravating, 25-(OH) D3 level gradually reduces. There is no relationship between VD-Ab and Vit D level.

Key words:

systemic lupus erythematosus; 25-hydroxy vitamin D3; vitamin D antibody