老年冠状动脉旁路移植术后应用痰热清注射液的疗效分析

Application effect of Tanreqing Injection in patients over 65 years with coronary artery bypass grafting

摘要:

目的 探讨痰热清注射液在心脏外科手术后辅助治疗的临床效果。方法 选取2014 年1 月-2016 年2 月于该院行冠状动脉旁路移植术560 例患者，共有122 例≥ 65 岁行冠状动脉旁路移植术的患者入选，随机分为治疗组和对照组，治疗组术后常规应用痰热清注射液联合头孢呋辛预防性治疗，对照组单用头孢呋辛预防性治疗。比较痰热清注射液的疗效，分析治疗组与对照组术后肺部并发症、呼吸机使用时间、重症监护时间、住院时间、患者体温变化及化验血常规等临床指标。结果 治疗组痰热清联合头孢呋辛的总有效率为95.08%（58/61），对照组单用头孢呋辛的总有效率为78.69%（48/61），经卡方检验，差异有统计学意义（P <0.05），痰热清联合头孢呋辛的有效率高于单用头孢呋辛。治疗组术后体温下降到正常时间、白细胞数下降到正常时间、呼吸机使用时间、住院时间与对照组比较，差异有统计学意义（P <0.05）。结论 ≥ 65 岁高龄患者行冠状动脉旁路移植术后应用痰热清注射液辅助治疗效果明显，痰热清注射液可减轻术后患者的炎症反应，为高龄患者术后平稳过度保驾护航。

Abstract:

Objective To explore the clinical effect of Tanreqing Injection in adjuvant therapy after cardiac surgery. Methods Retrospective study was carried out in 122 patients older than 65 in our department after coronary artery bypass grafting from January 2014 to February 2016. They were divided into two groups at random: the treatment group (61 cases) with postoperative routine application of Cefuroxime combined with Tanreqing Injection preventive treatment, the control group (61 cases) with simple Cefuroxime preventive therapy. The curative effect of Tanreqing injection was observed. The clinical indicators of both groups such as postoperative pulmonary complications, time of use of breathing machine, intensive care time, temperature changes of the patients, time under intensive care, length of hospital stay, and blood test were analyzed. Results The total effective rate of the treatment group (95.08%) was significantly higher than that of the control group (78.69%, P < 0.05). There were significant differences in the time of body temperature lowering to normal, the time of WBC returning to normal, the time of use of breathing machine and the time of hospital stay between the two groups (P < 0.05). Conclusions In the patients over 65 years, the effect of adjuvant treatment with Tanreqing injection is obvious after coronary artery bypass transplantation. It can reduce the postoperative inflammatory response and provide elderly patients with a stable postoperative rehabilitation. Its curative effect still needs further clinical observation.