脑苷肌肽注射液联合针灸对小儿周围性面瘫血清MDA、SOD和NO水平的影响

Effect of Brain Glycoside Peptide Injection combined with acupuncture on levels of MDA, SOD and NO in children with peripheral facial nerve palsy

摘要:

探讨脑苷肌肽注射液联合针灸对小儿周围性面瘫血清丙二醛（MDA）、超氧化物歧化酶（SOD）和一氧化氮NO水平的影响。方法选取2013 年1 月-2015 年6 月于青海省妇女儿童医院接受治疗的98 例周围性面瘫患儿作为研究对象，按照随机数字表法分为对照组49 例和观察组49 例。所有患儿均给予常规治疗，在此基础上，对照组给予针灸治疗，而观察组在对照组基础上联合脑苷肌肽注射液治疗。疗程结束后，比较两组患儿的临床疗效、面神经House-Brackmann 分级评分以及MDA、SOD、NO 水平和不良反应发生情况。结果疗效评价后，观察组治疗总有效率高于对照组（98.0% vs 83.7%，p <0.05）。治疗后，与对照组相比，观察组患儿面神经House-Brackmann 分级评分升高[（4.52±1.02）分vs（3.65±1.14）分]，血清MDA水平降低[（3.21±0.57）mmol/L vs（4.98±0.79）mmol/L]，SOD、NO 水平升高[（92.73±9.76）mIU/ml vs(60.51±8.67）mIU/ml，（79.15±8.82）μmol/L vs（50.78±7.34）μmol/L]，组间比较差异均具有统计学意义（均p<0.05）。治疗期间，两组患儿均未出现严重不良反应。结论脑苷肌肽注射液联合针灸治疗小儿周围性面瘫疗效良好，具有较高的治疗有效率，能够显著促进神经功能恢复，改善血清MDA、SOD、NO 水平，且不良反应轻微，临床上值得进一步研究。

Abstract:

To investigate the effect of Brain Glycoside Peptide Injection in combination with acupuncture on levels of malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) for patients with pediatric peripheral facial nerve palsy. Methods Ninety-eight children of peripheral facial nerve palsy who received therapy in our hospital from January 2013 to June 2015 were selected as research objects. According to random number table, they were divided into the control group (n = 49) and the observation group (n = 49). All patients were given conventional treatments. Besides that, the control group was given acupuncture, while the observation group was given Brain Glycoside Peptide Injection in combination with acupuncture. Then, the curative efficacy, House -Brackmann grading score for facial nerve, levels of serum MDA, SOD and NO, and adverse reactions were compared between the two groups. Results The observation group had a total effective rate of 98.0%, which was statistically higher than 83.7% of the control group (p < 0.05). After treatment, in comparison with the control group, the observation group had statistically higher House-Brackmann score for facial nerve [(4.52 ±1.02) vs (3.65 ±1.14)], lower level of serum MDA [(3.21 ±0.57) vs (4.98 ±0.79) mmol/L] and higher levels of serum SOD[(92.73 ±9.76) vs (60.51 ±8.67) mIU/ml] and NO [(79.15 ±8.82) vs (50.78 ±7.34) μmol/L] (p < 0.05). During the treatment, there was no severe adverse reaction in either group. Conclusions Brain Glycoside Peptide Injection in combination with acupuncture is effective for pediatric peripheral facial nerve palsy with high therapeutic efficacy. And it can significantly promote the recovery of neurological function and improve the levels of serum MDA, SOD and NO with mild adverse reactions.