益气复脉对中晚期肺癌患者免疫功能和生存质量的影响

Effects of Yiqifumai injection on immune function and quality of life in patients with advanced lung cancer

摘要:

 摘要：目的  探讨注射用益气复脉（冻干）对中、晚期肺癌患者免疫功能和生存质量的影响。方法  选取2013年9月-2014年8月在该院经组织病理学或细胞学确诊为中、晚期肺癌并化疗的患者63例为对照组；选择2015年1月-2015年12月该院同类患者67例为观察组。两组患者给予相同的化疗方案，辅助健康指导、营养支持、心理及康复锻炼指导，并给予止痛、止呕等治疗。观察组在对照组的基础上加用注射用益气复脉。6个疗程后比较两组的免疫功能血液学指标、生存质量、卡氏评分、疗效及不良反应。结果  观察组可降低C-反应蛋白和白细胞的数量，增加NKT细胞活性，增加T细胞亚群中CD3+、CD4+及CD4/CD8+的比例，增强机体的免疫功能。治疗前两组患者的生存质量评分差异无统计学意义，治疗后两组患者的生存质量均提高。观察组患者在认知功能和经济困难方面与对照组患者改善程度一致，在其他维度方面优于对照组。治疗后观察组患者卡氏评分与对照组比较，差异有统计学意义（P <0.05）。观察组患者显效率为95.52%，对照组为60.32%，差异有统计学意义（P <
0.05）。观察组白细胞计数下降、血小板计数下降、血红蛋白下降、肝功能异常、肾功能异常比例比较，差异有统计学意义（P <0.05）。结论  注射用益气复脉不仅可提高机体的免疫功能，而且可减少不良反应的发生，提高患者生存质量。

Abstract:

Abstract: Objective To investigate the effect of Yiqifumai injection (freeze-drying) on the immunity and quality of life in patients with advanced lung cancer. Methods In this study, 63 patients with advanced lung cancer who were diagnosed by pathology and cytology and accepted chemotherapy in our hospital from September 2013 to August 2014 were taken as control group, and 67 cases of the same kind of patients from January 2015 to December 2015 were selected as observation group. The patients in the two groups were given the same chemotherapy regimen and auxiliary health guidance, nutritional support, psychological and rehabilitation exercise guidance, as well as analgesics and antiemetics. The observation group had additional treatment of Yiqifumai injection. After 6 courses hematologic parameters of immune function, quality of life, Karnofsky score, curative effect and adverse reactions were compared between the two groups. Results In the observation group the amount of C-reactive protein and white blood cells was reduced (P < 0.05), the activity of NKT cells was increased, the proportions of CD3+ and CD4+ T cell subsets and CD4/CD8+ ratio were increased (P < 0.05). The immune function of the body was enhanced. The scores of quality of life of the patients in the two groups had no significant difference before treatment, but increased in both groups after treatment. The improvement in the cognitive function and economic difficulties was consistent in the two group, but that in the remaining dimensions was better in the observation group (P < 0.05). After treatment, the Karnofsky score of the observation group was significantly different from that of the control group (P < 0.05). The total effective rate was 95.52% in the observation group and 60.32% in the control group, and there was significant difference between the two groups (P < 0.05). In the observation group, white blood cell and platelet count and hemoglobin level decreased, abnormal liver and renal function was observed, and the differences between the two groups had statistical significance (P < 0.05). Conclusions Application of Yiqifumai injection can not only improve the patients' immune function, but also reduce the occurrence of adverse reactions and improve the quality of life of the patients.