汉族人系统性红斑狼疮和狼疮肾炎与IL-22受体基因多态性的关系

Relationships of systemic lupus erythematosus and lupus nephritis in Han population with IL-22 receptor gene polymorphisms

摘要:

摘要：目的  对汉族人群系统性红斑狼疮患者白细胞介素22（IL-22）受体基因多态性进行研究，探讨其与系统性红斑狼疮和狼疮肾炎的关系。方法  选取2012年1月-2016年6月吉林大学第一医院系统性红斑狼疮患者360例和健康者360例作为研究对象，将其分为A组（系统性红斑狼疮组）和B组（对照组）；系统性红斑狼疮患者分为C组（狼疮肾炎组）和D组（无狼疮肾炎组）。观察IL-22R1基因rs3795299位点基因型和等位基因频率与系统性红斑狼疮、狼疮肾炎及系统性红斑狼疮临床特点的关系。结果  A组与B组IL-22R1基因rs3795299位点基因型和等位基因频率比较，差异无统计学意义（P >0.05）。C组患者GG基因型所占比例高于D组患者（P <0.05），CG和CC基因型所占比例低于D组患者（P <0.05）；C组患者等位基因G频率低于D组（P <0.05），等位基因C频率高于D组（P <0.05）。IL-22R1基因rs3795299位点等位基因频率在系统性红斑狼疮患者有关节炎、面部红斑、光敏感和口腔溃疡患者中的分布与无关节炎、面部红斑、光敏感和口腔溃疡患者中的分布不同，差异有统计学意义（P <0.05）。结论  在中国汉族人群中，IL-22R1基因rs3795299位点基因多态性与系统性红斑狼疮的易感性无关，与狼疮肾炎的易感性有关，与系统性红斑狼疮的临床特点相关。

Abstract:

 Abstract: Objective To study the interleukin-22 (IL-22) receptor gene polymorphisms in Han patients with systemic lupus erythematosus (SLE), and to examine its relationships with SLE and lupus nephritis. Methods A total of 360 patients with SLE (group A) and 360 health people (control group) in the First Hospital of Jilin University from January 2012 to June 2016 were selected as research subjects. The group A was further divided into group C (lupus nephritis group) and group D (without lupus nephritis group). The correlations of rs3795299 genotypes and allele frequency of IL-22R1 gene with SLE, lupus nephritis and clinical characteristics of SLE were observed. Results The differences in the rs3795299 genotypes and allele frequency of IL-22R1 gene were not statistically significant between the group A and the group B (P > 0.05). The proportion of GG genotype in the group C was higher than that in the group D (P < 0.05), while the proportions of CG and CC genotypes in the group C were lower than those in the group D (P < 0.05). The frequency of allele G in the group C was lower than that in the group D (P < 0.05), but the frequency of allele C in the group C was higher than that in the group D (P < 0.05). The distribution of allele frequency of rs3795299 locus in IL-22R1 gene was significantly different between the SLE patients with arthritis, facial redness, light sensitivity or oral ulcers and the SLE patients without arthritis, facial redness, light sensitivity or oral ulcers (P < 0.05). Conclusions In Chinese Han population, IL-22R1 gene rs3795299 gene polymorphism is not in significant correlation with the susceptibility of SLE, but is related to lupus nephritis and clinical features of SLE.