舒芬太尼在老年结肠癌术后的应用对SOFA评分的影响

Influence of Sufentanil on postoperative SOFA scores in elderly patients with colon cancer

摘要:

评价舒芬太尼在老年高血压结肠癌根治术后应用对SOFA 评分的影响，并与芬太尼比较。方法选取武汉市第一医院择期行结肠癌手术治疗的老年高血压患者，随机分为舒芬太尼组与芬太尼组，术后给予镇痛治疗，舒芬太尼0.1～0.2μg/（kg·h）维持；芬太尼组：0.5～2.0μg/（kg·h）维持，比较各时间点的SOFA评分。结果舒芬太尼组内比较：术后入ICU 后SOFA 评分与各时间点SOFA 评分比较，差异具有统计学意义（p <0.05）。芬太尼组内比较：术后入ICU 后SOFA 评分与术后48 和72 h的SOFA 评分差异具有统计学意义（p <0.05）；术后入ICU后SOFA 评分与术后24 h 的评分差异不具有统计学意义（p >0.05）。两组组间比较：与芬太尼组术后SOFA 评分比较，舒芬太尼组术后24、48 和72 h SOFA 评分差异具有统计学意义（ p<0.05）。结论舒芬太尼用于重症患者具有良好的镇痛作用；舒芬太尼对重症患者术后SOFA 评分的改变效果显著。

Abstract:

To evaluate the influence of Sufentanil on SOFA scores in elderly hypertensive patients after radical resection of colon and compare with Fentanyl. Methods Elderly patients with hypertension undergoing elective colorectal surgery in Wuhan First Hospital were selected and randomly divided into Sufentanil group and Fentanyl group. Postoperative analgesia was given, Sufentanil 0.1-0.2 μg/(kg·h) was used for maintenance in the Sufentanil group, while Fentanyl 0.5-2.0 μg/(kg·h) was given for maintenanc in the Fentanyl group. SOFA scores were compared between the two groups at each time point. Results In the Sufentanil group, the SOFA scores after entering into ICU after surgery were significantly different from those at each time point ( μ< 0.05). Within the Fentanyl group, the SOFA scores after entering into ICU after surgery were significantly different from those at the 48th and 72th h after operation ( p< 0.05). The SOFA scores of the Fentanyl group were significantly different from those of the Sufentanil group 24, 48 and 72 h after surgery ( p< 0.05). Conclusions Sufentanil has good analgesic effect for critically ill patients, and can significantly improve postoperative SOFA scores of the patients.