血清高迁移率族蛋白1在乙型肝炎病毒相关肝衰竭患者中的表达及其临床意义

Expression of HMGB1 in patients with hepatitis B virus-related liver failure and its significance

摘要:

探讨血清高迁移率族蛋白1（HMGB1）在乙型肝炎病毒（HBV）相关肝衰竭患者中的表达及其临床意义。方法选取乙型肝炎病毒相关肝衰竭患者90 例，分为早期组（A 组）、中期组（B 组）和晚期组（C组）相关的生物化学指标和HMGB1 水平，研究HMGB1 表达水平及其临床意义。采用独立样本的检验和方差分析进行组间数据比较，并用多元线性回归分析预测组间的相关性。结果血清HMGB1 水平检测结果表明：A 组、B 组、C 组和E 组患者血清中HMGBl 均为阳性，分别为（7.54±2.5）、（12.05±3.7）、（18.69±5.4）和（5.26±4.0）μg/L。D组血清中HMGB1 均为阴性。HBV 患者血清HMGBl 水平高于慢性乙型肝炎患者（t =2.863，p =0.008）；晚期HBV 患者血清HMGB1 水平高于早期患者（t =2.178，p =0.030）；HBV 患者血清HMGBl水平与AST 水平呈正相关（ t=0.695，p =0.005）。结论HBV 相关肝衰竭患者血清HMGB1 水平随病情发展呈进行性升高，可部分预测HBV 相关肝衰竭患者的预后。

Abstract:

To investigate the expression of serum high mobility group protein 1 (HMGB1) in patients with hepatitis B virus (HBV)-related liver failure and its clinical significance. Methods Ninety patients of HBVrelated liver failure were divided into early group (group A), middle group (group B) and late group (group C) with 30 cases in each group. In addition, 30 cases of healthy persons (group D) and 30 cases of chronic hepatitis B patients(group E) were used as control groups. Serum levels of biochemical indexes related to liver function and HMGB1 were detected in each group. The test and variance analysis of independent samples were used to compare the data between the groups, and the correlations between the groups were predicted by multiple linear regression analysis. Results The patients of the groups A, B, C and E were HMGB1 positive, their serum levels of HMGB1 were (7.54 ±2.5), (12.05 ±3.7), (18.69 ±5.4) and (5.26±4.0) μg/L, respectively. The patients of the group D were HMGB1 negative. The patients with HBV-related liver failure had significantly higher serum level of HMGB1 than the patients in the group E ( t= 2.863,p < 0.05). The patients in the group C had significantly higher serum level ofHMGB 1 than those in the group A ( t= 2.178, p< 0.05). The serum HMGB1 level was positively correlated with the AST level in the patients with HBV-related liver failure (t = 0.695,p < 0.05). Conclusions The serum HMGB 1 level in the patients with HBV-related liver failure increases with the progression of the disease, which could partially predict the prognosis of the patients.