普罗布考对脑梗死患者氧化应激水平、尿酸及临床预后的影响

Effect of Probucol on oxidative stress level, uric acid and clinical prognosis in patients with cerebral infarction

摘要:

目的研究普罗布考对脑梗死患者氧化应激水平、尿酸及临床预后的影响。方法将160 例缺血性脑卒中患者随机分为实验组和对照组两组，除基础治疗外，实验组予以阿托伐他汀钙片联合普罗布考治疗，对照组予阿托伐他汀治疗。于入院第1 天和第14 天分别测定缺血性卒中患者的超氧化物歧化酶（SOD）、总抗氧化能力（TAC）、丙二醛（MDA）及尿酸水平，于发病第90 天应用改良Rankin量表评价其神经功能。分析普罗布考与氧化应激水平、尿酸及临床预后的关系。结果两组卒中进展比例比较，差异有统计学意义（P <0.05），实 验组低于对照组。两组第90 天时的神经功能比较，差异有统计学意义（P <0.05），实验组优于对照组。通过比较两组间氧化应激水平发现，普罗布考可以降低脑梗死患者的氧化应激及尿酸水平，进一步改善患者的神经功能。结论普罗布考可以通过降低脑梗死患者的氧化应激及尿酸水平，改善患者预后。

Abstract:

Objective To study the effect of Probucol on serum uric acid, oxidative stress level and prognosis in patients with ischemic stroke. Methods One hundred and sixty patients with ischemic stroke were randomly divided into experimental group and control group. On the basis of basic treatment, the experimental group was treated with Atorvastatin and Probucol, the control group was treated with Atorvastatin only. Superoxide dismutase (SOD), total antioxidant capacity (TAC), malondialdehyde (MDA) and uric acid (UA) levels were measured in patients with ischemic stroke on the 1st day and the 14th day respectively. The neurological function was evaluated with the modified Rankin Scale on the 90th day. The correlations of Probucol with oxidative stress level, uric acid and clinical prognosis were analyzed. Results The rate of progressive stroke in the experimental group was significantly lower than that in the control group (P < 0.05). The neurological function of the experimental group was significantly better than that in the control group on the 90th day (P < 0.05). By comparing the levels of oxidative stress between the two groups, it was found that Probucol significantly decreased the levels of oxidative stress and uric acid, and improved the neurological function in the patients with cerebral infarction (P < 0.05). Conclusions Probucol can improve the prognosis of the patients with cerebral infarction by reducing the levels of oxidative stress and uric acid.