Smad4 在老年喉鳞癌患者中的表达及其临床意义

Expression of Smad4 in laryngeal squamous cell carcinoma of elderly patients and significance

摘要:

目的 探讨Smad4 在老年喉鳞癌患者中的表达及其临床意义。方法 应用免疫组织化学法检测65 对老年喉鳞癌患者及癌旁正常黏膜组织中Smad4 的表达。结果 老年患者喉鳞癌组织中Smad4 蛋白阳性表达率低于癌旁正常黏膜组织（P <0.05）。Smad4 表达水平与喉鳞癌分化程度、淋巴结转移有关（P <0.05）。结论 Smad4 可促进喉癌的发生、发展，可能在喉癌分化、浸润、转移过程中发挥重要作用。

Abstract:

Objective To observe the expression of Smad4 protein in laryngeal squamous cell carcinoma of elderly patients and investigate the relationships between Smad4 protein expression and clinical pathological features. Methods Immunohistochemical technique was used to detect the expression of Smad4 protein in 65 tissues of laryngeal squamous cell carcinoma and paired para-carcinoma tissues. Results The positive rate of Smad4 in the laryngeal squamous cell carcinoma was obviously lower than that in the para-carcinoma tissues (P < 0.05). The Smad4 protein expression in the laryngeal squamous cell carcinoma had correlations with differentiated degree of laryngeal squamous cell carcinoma and lymph node metastasis (P < 0.05). Conclusions Smad4 may contribute to the carcinogenesis and development of laryngeal squamous cell carcinoma and play an important role in the process of differentiation, infiltration and metastasis of laryngeal squamous cell carcinoma.