泪小点栓塞术对中度混合型干眼的疗效观察

Curative effect of lacrimal point embolization on moderate mixed xerophthalmia

摘要:

观察泪小点栓塞术对中度混合型干眼患者眼部症状体征及炎症因子的影响，评价泪小点栓塞术对中度混合型干眼的疗效。方法对中度混合型干眼患者行泪小点栓塞术。对患者术前、术后30 和60 d的OSDI 评分、泪膜破裂时间（TBUT）、泪液分泌实验（未表面麻醉的Schirmer I）以及角膜荧光染色评分进行评估，并且测量泪液中炎症因子IL-1β、金属蛋白酶9（MMP-9）及TNF-α的表达，比较上述指标的变化。结果34 例（68 眼）中度混合型干眼患者术后与术前相比，干眼患者OSDI 评分、角膜荧光染色评分下降，差异有统计学意义（p <0.05）；而泪液分泌实验、泪膜破裂时间差异无统计学意义（p >0.05）；泪液中炎症因子IL-1β,MMP-9 及TNF-α的水平均出现了不同程度的降低,差异有统计学意义（p <0.05）。结论泪小点栓塞术能改善中度混合型干眼患者的眼部症状体征，降低眼表炎症因子的水平。

Abstract:

To observe the effect of lacrimal point embolization on eye symptoms and signs and inflammatory factors in patients with moderate mixed xerophthalmia, and to evaluate the curative effect. Methods Lacrimal punctum embolization was applied to the patients with moderate mixed dry eyes. OSDI scores, tear film break-up time (TBUT), Schirmer test (not table linen Schirmer I), corneal fluorescein staining scores were assessed before operation and 30 and 60 d after operation. The inflammatory factors IL-1β, matrix metalloproteinase-9 (MMP -9) and tumor necrosis factor alpha (TNF -α) were measured, and the changes in these indicators were compared. Results Lacrimal point embolization was performed on the 68 eyes of the 34 patients with moderate mixed xerophthalmia. OSDI scores and corneal fluorescence staining score significantly decreased 30 and 60 d after operation compared to those before operation (p < 0.05). TBUT and Schirmer test showed no significant differences.The levels of IL-1β, MMP-9 and TNF-α in tears reduced in different degree after operation, the differences had statistical significance (p < 0.05). Conclusions Lacrimal point embolization can improve symptoms and signs of the eyes of the patients with moderate mixed xerophthalmia and lower the levels of inflammatory factors.