3 种亚型IPD 患者的T2* 值定量研究

Quantitative study on T2*value of three subtypes of movement disorder in Parkinson’s disease

摘要:

目的 研究原发性帕金森病（IPD）及不同运动障碍亚型分型诊断T2* 值的价值。方法 对122 例IPD 患者与年龄、性别相匹配的对照组进行常规序列、增强梯度回波T2* 加权血管成像序列扫描。分别测量左右侧额叶白质区、红核、黑质网状带、黑质致密带、尾状核头、壳核、苍白球及丘脑的T2* 值。结果 姿势异常、步态障碍（PIGD）为主型IPD 组与对照组在红核和黑质致密带的T2* 值比较，差异有统计学意义（P <0.05）。PIGD 为主型IPD 组与混合型IPD 组在红核、黑质网状部、壳核、苍白球及丘脑的T2* 值比较，差异有统计学意义（P <0.05）。PIGD 为主型IPD 组与震颤为主型IPD 组在丘脑的T2* 值比较，差异有统计学意义（P <0.05）。震颤为主型IPD 组与混合型IPD 组在黑质网状部、壳核的T2* 值比较，差异有统计学意义（P <0.05）。结论 T2* 值有助于IPD 及不同运动障碍亚型分型诊断。

Abstract:

Objective To investigate the role of T2* value in diagnosing idiopathic Parkinson’s disease (IPD) and identifying different subtypes of movement disorder. Methods A total of 122 patients with IPD and 122 control subjects with matched age and gender, were scanned with routine sequences and ESWAN sequences. T2* value was measured in both sides of frontal white matter (FWM), red nucleus (RN), substantia nigra pars reticulate (SNr), substantia nigra pars compacta (SNc), putamen (PUT), globus pallidus (GP), head of caudate nucleus (CN) and thalamus (THA), and statistically analyzed. Results The T2* values of RN and SNc differed significantly between the postural instability and gait disorder (PIGD)-dominant IPD patients and the control group (P < 0.05);the T2* values of RN, SNr, PUT, GP and THA were significantly different between the PIGD-dominant IPD and the mixed subtype IPD (P < 0.05); the T2* value of THA was significantly different when the PICD-dominant IPD was compared with the tremor-dominant IPD (P < 0.05); and the T2* values of SNr and PUT were significantly different when the tremor-dominant IPD was compared with the mixed subtype IPD (P < 0.05). Conclusions The T2* value helps to diagnose IPD and distinguish different subtypes of movement disorder.