Abstract:Objective To investigate the correlation between sustained increase of hypersensitive C-reactive protein (hs-CRP) and progressive cerebral infarction. Methods A total of 136 patients with acute cerebral infarction from January 2014 to March 2016 were enrolled for the study and divided into sustained increase group and non-sustained increase group according to the level of hs-CRP at admission, 48 and 72 hours after onset. And they were divided into progressive group and non-progressive group according to whether progressive cerebral infarction occurred. Baseline data, clinical indicators, National Institute of Health Stroke Scale (NIHSS) score at admission, fever and carotid artery stenosis were compared among the groups. Multivariate logistic regression analysis was performed to screen out the factors related to hs-CRP sustained growth and progressive cerebral infarction. Results In all patients, progressive cerebral infarction occurred in 50 cases (36.8%) and hs-CRP sustained growth occurred in 47 cases (34.6%). The incidence of hs-CRP sustained growth in the progressive group was 54.0% (27/50), which was significantly higher than 23.3% (20/86) in the non-progressive group (P < 0.05).Multivariate logistic regression analysis showed that the history of diabetes, triglyceride (TG) and blood WBC count were the influencing factors for hs-CRP sustained growth (P < 0.05). Fasting plasma glucose, NHISS score, fever and sustained growth of hs-CRP were the influencing factors for progressive cerebral infarction(P < 0.05). Conclusions Progressive cerebral infarction is related to sustained increase of hs-CRP. The serum level of hs-CRP is significantly increased in the patients with progressive cerebral infarction.
