雄激素对青藏高原地区中年妇女体脂含量和分布的影响

Effect of androgens on content and distribution of body fat of middle-aged women from Qinghai-Tibet plateau

摘要:

目的探讨青藏高原地区雄激素对中年妇女体脂的影响。方法选取2014年6 月-2015 年5 月在青海红十字医院进行体检的116 名健康妇女作为研究对象，根据月经状态将所有患者分为生育期（n =31）、绝经过渡期（n =26）和绝经后期（ n=59）。比较3 组的年龄、体重指数（BMI）、体脂指标以及血脱氢表雄酮（DHEA）、性激素结合球蛋白（SHBG）、总睾酮（TT）及游离雄激素指数（FAI）等水平。采用Pearson相关系数分析体脂指标和雄激素的关系。结果生育期妇女的年龄、躯干脂肪占全身脂肪含量的百分比、A/G 均低于其他两组（p <0.05），男性区域的脂肪比例低于绝经后期妇女。绝经过渡期妇女的年龄、躯干脂肪占全身脂肪含量的百分比低于绝经后期妇女，差异有统计学意义（p <0.05）。绝经后期的TT、FAI均低于其他两组，差异有统计学意义（p <0.05）。Pearson 分析结果表明，TT 与BMI、全身脂肪组织的总含量及比例呈正相关（p <0.05），FAI 与BMI、全身脂肪组织的总含量及比例、男性区域的脂肪比例、A/G 呈正相关（p <0.05）。结论青藏高原地区中年妇女的雄激素水平越高，体脂含量也更多，更趋向于中心性分布，但雄激素可能不是主要影响因素。

Abstract:

Objective To investigate the effect of androgens on content and distribution of body fat of middleaged women from Qinghai-Tibet plateau. Methods In the study 116 healthy women aged 40-60 years who received medical examination from June 2014 to May 2015 in our hospital were enrolled, and divided into reproductive stage (31 cases), perimenopausal stage (26 cases) and postmenopausal stage (59 cases) three groups. Age, body mass index (BMI), index of body fat, blood dehydroepiandrosterone (DHEA), sex hormone binding globulin (SHBG), total testosterone (TT) and free androgen index (FAI) were compared among the three groups. Pearson correlation coefficient was performed to analyze the relationship between body fat and androgen. Results Age, percentage of trunk fat to body fat and A/G ratio in the reproductive stage group were significantly lower than those in the other two groups (p < 0.05), adipose percentage of android area was significantly lower than that in the postmenopausal stage group (p < 0.05). Age and percentage of trunk fat to body fat in the perimenopausal stage group were significantly lower than those in the postmenopausal stage group (p < 0.05). TT and FAI in the postmenopausal stage group were significantly lower than those in the other two groups (p < 0.05). Pearson analysis results showed that TT was positively correlated with BMI, total body fat content and ratio (p < 0.05), while FAI was positively correlated with BMI, total body fat content and ratio, adipose percentage of android area and A/G (p < 0.05). Conclusions For middle-aged women from Qinghai-Tibet plateau, the higher the androgen level, the more the body fat content and the more centrally distributed the body fat. But androgen may not be the main influencing factor.